Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Regulation of protein synthesis, intracellular electrolytes and cataract formation in vitro

Abstract

Control of protein synthesis is associated with changes in the ratio of intracellular Na+ to K+ in the cultured embryonic chick lens. Correlations of intracellular Na+/K+ ratios with crystallin synthesis and cataract formation in vitro suggest that the Na+/K+ ratio may have an important role in the regulation of protein synthesis during cataractogenesis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Cataract and Abnormalities of the Lens (ed. Bellows, J. G.) (Grune and Stratton, New York, 1975).

  2. Kinoshita, J. H. Invest. Ophthal. 13, 713–724 (1974).

    CAS  PubMed  Google Scholar 

  3. Benedek, G. B. Appl. Opt. 10, 459–473 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Spector, A. Isr. J. med. Sci. 8, 1577–1582 (1972).

    CAS  PubMed  Google Scholar 

  5. Jedziniak, J. A., Kinoshita, J. H., Yates, E. M., Hocker, L. O. & Benedek, G. B. Invest. Ophthal. 11, 905–915 (1972).

    CAS  PubMed  Google Scholar 

  6. Piatigorsky, J. & Shinohara, T. Science 196, 1345–1347 (1977).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Ham, R. G. Expl Cell Res. 29, 515–526 (1963).

    Article  CAS  Google Scholar 

  8. Clayton, R. M. in The Eye vol. 5 (eds Davson, H. & Graham, L. T.) 400–494 (Academic, London, 1974).

    Google Scholar 

  9. Rabaey, M. Expl Eye Res. 1, 310–316 (1962).

    Article  CAS  Google Scholar 

  10. Zwaan, J. & Ikeda, A. Expl Eye Res. 7, 301–311 (1968).

    Article  CAS  Google Scholar 

  11. Genis-Galvez, J. M., Maisel, H. & Castro, J. M. Expl Eye Res. 7, 593–602 (1968).

    Article  CAS  Google Scholar 

  12. Yoshida, K. & Katoh, A. Expl Eye Res. 11, 184–194 (1971).

    Article  CAS  Google Scholar 

  13. Piatigorsky, J., Webster, H. deF. & Craig, S. P. Devl Biol. 27, 176–189 (1972).

    Article  CAS  Google Scholar 

  14. Reszelbach, R., Shinohara, T. & Piatigorsky, J. Expl Eye Res. (in the press).

  15. Chylack, L. T., Jr & Kinoshita, J. H. Invest. Ophthal. 8, 401–412 (1969).

    CAS  PubMed  Google Scholar 

  16. Andrée, G. Ber. Versamm. dt. ophthal. Ges. 70, 354–358 (1970).

    Google Scholar 

  17. Iwata, S. & Kinoshita, J. H. Invest. Ophthal. 10, 504–512 (1971).

    CAS  PubMed  Google Scholar 

  18. van Heyningen, R. Expl Eye Res. 13, 136–147 (1972).

    Article  CAS  Google Scholar 

  19. Maraini, G. & Mangili, R. Ciba Fn Symp. 19 (new ser.), 79–97 (1973).

    Google Scholar 

  20. Duncan, G. & Bushell, A. R. Expl Eye Res. 20, 223–230 (1975).

    Article  CAS  Google Scholar 

  21. Chylack, L. T., Jr & Kinoshita, J. H. Expl Eye Res. 14, 58–64 (1972).

    Article  Google Scholar 

  22. Chylack, L. T., Jr & Kinoshita, J. H. Expl Eye Res. 15, 61–69 (1973).

    Article  Google Scholar 

  23. Lubin, M. & Ennis, H. L. Biochim. biophys. Acta 80, 614–631 (1964).

    CAS  PubMed  Google Scholar 

  24. Lubin, M. Nature 213, 451–453 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  25. Carrasco, L. & Smith, A. E. Nature 264, 807–809 (1976).

    Article  ADS  CAS  PubMed  Google Scholar 

  26. Kuck, J. F. R., Jr. in Biochemistry of the Eye (ed. Graymore, C. N.) 183–260 (Academic, London, 1970).

    Google Scholar 

  27. Dahl, J. L. & Hokin, L. E. A. Rev. Biochem. 43, 327–356 (1974).

    Article  CAS  Google Scholar 

  28. Kinoshita, J. H., Kern, H. L. & Merola, L. O. Biochim. biophys. Acta 47, 458–466 (1961).

    Article  CAS  PubMed  Google Scholar 

  29. Bonting, S. L., Caravaggio, L. L. & Hawkins, N. M. Archs Biochem. Biophys. 101, 47–55 (1963).

    Article  CAS  Google Scholar 

  30. Bonting, S. L. Invest. Ophthal. 4, 723–738 (1965).

    CAS  PubMed  Google Scholar 

  31. Harris, J. E. & Becker, B. Invest. Ophthal. 4, 709–722 (1965).

    CAS  PubMed  Google Scholar 

  32. Becker, B. & Cotlier, E. Invest. Ophthal. 1, 642–645 (1962).

    CAS  PubMed  Google Scholar 

  33. Kinsey, V. E. & Reddy, D. V. N. Invest. Ophthal. 4, 104–116 (1965).

    CAS  PubMed  Google Scholar 

  34. Riley, M. V. Expl Eye Res. 9, 28–37 (1970).

    Article  CAS  Google Scholar 

  35. Duncan, G. Ciba Fn Symp. 19 (new ser.), 99–116 (1973).

    Google Scholar 

  36. Kinsey, V. E. Eye Structure, II Symp. (ed. Rohen, J. W.) 383–394 (Schattauer, Stuttgart, 1965).

    Google Scholar 

  37. Spector, A. Invest. Ophthal. 4, 579–591 (1965).

    CAS  PubMed  Google Scholar 

  38. Bloemendal, H. Science 197, 127–138 (1977).

    Article  ADS  CAS  PubMed  Google Scholar 

  39. Piatigorsky, J., Zelenka, P. & Simpson, R. T. Expl Eye Res. 18, 435–446 (1974).

    Article  CAS  Google Scholar 

  40. Piatigorsky, J. J. biol. Chem. 251, 4416–4420 (1976).

    CAS  PubMed  Google Scholar 

  41. Sonenshein, G. E. & Brawerman, G. Biochemistry 15, 5497–5501 (1976).

    Article  CAS  PubMed  Google Scholar 

  42. Saborio, J. L., Pong, Sheng-Shung & Koch, G. J. molec. Biol. 85, 195–211 (1974).

    Article  CAS  PubMed  Google Scholar 

  43. Nuss, D. L., Oppermann, H. & Koch, G. Proc. natn. Acad. Sci. U.S.A. 72, 1258–1262 (1975).

    Article  ADS  CAS  Google Scholar 

  44. Nuss, D. L. & Koch, G. J. Virol. 17, 283–286 (1976).

    CAS  PubMed Central  Google Scholar 

  45. Schochetman, G. & Schlom, J. Virology 73, 431–441 (1976).

    Article  CAS  PubMed  Google Scholar 

  46. Lodish, H. J. biol. Chem. 246, 7131–7138 (1971).

    CAS  PubMed  Google Scholar 

  47. McKeehan, W. L. J. biol. Chem. 249, 6517–6526 (1974).

    CAS  PubMed  Google Scholar 

  48. Sonenshein, G. E. & Brawerman, G. Biochemistry 15, 5501–5506 (1976).

    Article  CAS  PubMed  Google Scholar 

  49. Lodish, H. A. Rev. Biochem. 45, 39–72 (1976).

    Article  CAS  Google Scholar 

  50. Zelenka, P. & Piatigorsky, J. Expl Eye Res. 22, 115–124 (1976).

    Article  CAS  Google Scholar 

  51. Delcour, J. & Papaconstantinou, J. Biochem. biophys. Res. Commun. 57, 134–141 (1974).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shinohara, T., Piatigorsky, J. Regulation of protein synthesis, intracellular electrolytes and cataract formation in vitro. Nature 270, 406–411 (1977). https://doi.org/10.1038/270406a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/270406a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing