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Identification of the herpes simplex virus DNA polymerase gene

Nature volume 269, pages 621–623 (1977)Cite this article

Abstract

THERE is at present much interest in the herpes viruses because they have been associated with human cancer and cause latent infections with recurrent disease. They are also of interest because they form a relatively simple but apt model for the processes of transcription and DNA replication in eukaryotic cells. We have studied the virus-induced proteins involved in DNA replication, and present here results that give definitive evidence that the virus-induced DNA polymerase is encoded in the virus genome, that locate the gene for virus DNA polymerase, and also show that the enzyme is essential for virus replication.

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References

  1. Keir, H. M. & Gold, E. Biochim. biophys. Acta 72, 263–276 (1963).

    Article  CAS  Google Scholar 

  2. Keir, H. M., Subak-Sharpe, H., Sheddon, W. I. H., Watson, D. H. & Wildy, P. Virology 30, 154–157 (1966).

    Article  CAS  Google Scholar 

  3. Keir, H. M., Hay, J., Morrison, J. M. & Subak-Sharpe, H. Nature 210, 369–371 (1966).

    Article  CAS  ADS  Google Scholar 

  4. Weissbach, A., Hong, S.-C. L., Aucker, J. & Muller, R. J. biol. Chem. 248, 6270–6277 (1973).

    CAS  PubMed  Google Scholar 

  5. Powell, K. L. & Purifoy, D. J. M. J. Virol. 24 (inthe press).

  6. Aron, G. M., Purifoy, D. J. M. & Schaffer, P. A. J. Virol. 16, 498–507 (1975).

    Article  CAS  Google Scholar 

  7. Purifoy, D. J. M. & Benyesh-Melnick, M. Virology 68, 374–386 (1975).

    Article  CAS  Google Scholar 

  8. Schaffer, P. A., Aron, G. M., Biswal, N. & Benyesh-Melnick, M. Virology 52, 57–71 (1973).

    Article  CAS  Google Scholar 

  9. Purifoy, D. J. M. & Powel, K. L. J. Virol. 24 (in the press).

  10. Overby, L. R. et al. Antimicrobial Agents & Chemother. 6, 360–365 (1974).

    Article  CAS  Google Scholar 

  11. Hay, J. & Subak-Sharpe, J. H. J. gen. Virol. 31, 145–145 (1976).

    Article  CAS  Google Scholar 

  12. Honess, R. W. & Watson, D. H. J. Virol. 21, 584–600 (1977).

    Article  CAS  Google Scholar 

  13. Purifoy, D. J. M. & Powell, K. L. J. Virol. 19, 717–731 (1976).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Virology and Epidemiology, Baylor College of Medicine, Houston, Texas, 77030

    DOROTHY J. M. PURIFOY, ROBERT B. LEWIS & KENNETH L. POWELL

Authors
  1. DOROTHY J. M. PURIFOY
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  2. ROBERT B. LEWIS
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  3. KENNETH L. POWELL
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PURIFOY, D., LEWIS, R. & POWELL, K. Identification of the herpes simplex virus DNA polymerase gene. Nature 269, 621–623 (1977). https://doi.org/10.1038/269621a0

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