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Circadian rhythm in cerebrospinal fluid noradrenaline of man and monkey

Nature volume 264, pages 656–658 (1976)Cite this article

Abstract

BRAIN areas with the highest concentration of noradrenergic nerve terminals and noradrenaline (NA) have a circadian rhythm in their content of NA in the rabbit, rat and cat. The anterior and lateral hypothalamus1 and cervical spinal cord2, midbrain3 and caudate nucleus4, medial lower brain stem5 and frontal cortex6 all have significant circadian variations in their NA content. These brain regions have their highest NA level during the night in the rat, a nocturnal animal, and during the day in the rabbit and cat.

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References

  1. Manshardt, J., and Wurtman, R. J., Nature, 217, 574–575 (1968).

    Article  ADS  CAS  Google Scholar 

  2. Reis, D. J., and Wurtman, R. J., Life Sci., 7, 91–98 (1968).

    Article  CAS  Google Scholar 

  3. Reis, D. J., Weinbren, M., and Corvelli, A., J. Pharmac. exp. Ther., 164, 135–145 (1968).

    CAS  Google Scholar 

  4. Freidman, A. H., and Walker, C. A., J. Physiol., Lond., 197, 77–85 (1968).

    Article  Google Scholar 

  5. Lew, G. M. and Quay, W. B., Comp. Gen. Pharmac., 4, 375–381 (1973).

    Article  CAS  Google Scholar 

  6. Eleftheriou, B. S., Brain Res., 75, 145–152 (1974).

    Article  CAS  Google Scholar 

  7. Ziegler, M. G., et al., Brain Res., 108, 436–440 (1976).

    Article  CAS  Google Scholar 

  8. Meyer, J. S., et al., Brain, 97, 655–664 (1974).

    Article  Google Scholar 

  9. Denker, S. J., Häggendal, J., and Ilves-Häggendal, M., Acta physiol. scand., 69, 140–146 (1967).

    Article  Google Scholar 

  10. Cummins, B. H., and Lothian, D., Br. J. Surg., 60, 910 (1973).

    CAS  PubMed  Google Scholar 

  11. Fuxe, K., and Ungerstedt, U., Eur. J. Pharmac., 4, 135–144 (1968).

    Article  CAS  Google Scholar 

  12. Fuxe, K., and Ungerstedt, U., Life Sci., 5, 1817 (1966).

    Article  CAS  Google Scholar 

  13. Henry, D. P., et al., Life Sci., 16, 375–384 (1975).

    Article  CAS  Google Scholar 

  14. Ebert, M. H., Post, R. M., and Goodwin, F. K., Lancet, ii, 776 (1972).

    Google Scholar 

  15. Hutchins, D. A. and Rogers, K. J., Psychopharmacologia, 31, 343–348 (1973).

    Article  CAS  Google Scholar 

  16. Evans, H. L., Ghiselli, W. B., and Patton, R. A., J. Pharmac. exp. Ther., 186, 10–17 (1973).

    CAS  Google Scholar 

  17. Segal, D. S., McAllister, C., and Geyer, M. A., Pharmac. Biochem. Behav., 2, 79–86 (1974).

    Article  CAS  Google Scholar 

  18. Collu, R., et al., Can. J. Physiol. Pharmac., 51, 890–892 (1973).

    Article  CAS  Google Scholar 

  19. Zigmond, M. J., and Wurtman, R. J., J. Pharmac. exp. Ther., 172, 416–422 (1970).

    CAS  Google Scholar 

  20. Brownstein, M., and Axelrod, J., Science, 184, 163–165 (1974).

    Article  ADS  CAS  Google Scholar 

  21. Black, I. B., Parker, L., and Axelrod, J., Biochem. Pharmac., 18, 2688–2691 (1969).

    Article  CAS  Google Scholar 

  22. Meyer, J. S., et al., Brain, 96, 277–288 (1973).

    Article  CAS  Google Scholar 

  23. Ciplea, A. L., Bubvianu, G., and Galasnu, E., Int. J. Neuropharmac., 3, 583–592 (1964).

    Article  CAS  Google Scholar 

  24. Post, R. M., et al., Science, 179, 1002–1003 (1973).

    Article  ADS  CAS  Google Scholar 

  25. Wilk, S., et al., Nature, 235, 440 (1972).

    Article  ADS  CAS  Google Scholar 

  26. Stein, L. and Wise, C. D., Science, 171, 1032–1036 (1971).

    Article  ADS  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Surgical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institute of Health, Bethesda, Maryland, 20014

    J. H. WOOD

  2. Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland, 20014

    M. G. ZIEGLER, C. R. LAKE & M. H. EBERT

Authors
  1. J. H. WOOD
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  2. M. G. ZIEGLER
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  3. C. R. LAKE
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  4. M. H. EBERT
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WOOD, J., ZIEGLER, M., LAKE, C. et al. Circadian rhythm in cerebrospinal fluid noradrenaline of man and monkey. Nature 264, 656–658 (1976). https://doi.org/10.1038/264656a0

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