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Long range homogeneity of physical stability in double-stranded DNA

Nature volume 263, pages 439–440 (1976)Cite this article

Abstract

WE present here evidence for the existence of regions with homogeneous physical stability (homostability regions) in double-stranded DNAs. Results of a study on the thermal melting of whole replicative form DNA from fd phage and of its fragments obtained by the action of restriction enzymes, strongly suggest that regional homostability seems to be an intrinsic characteristic of DNA, playing an essential part in its genetic activities.

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Authors and Affiliations

  1. Department of Physics, Faculty of Science, The University of Tokyo, Tokyo, Japan

    AKIYOSHI WADA & HIDEKI TACHIBANA

  2. Saitama Cancer Center Research Institute, Ina-machi, Saitama, Japan

    OSAMU GOTOH

  3. Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan

    MITSURU TAKANAMI

Authors
  1. AKIYOSHI WADA
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  2. HIDEKI TACHIBANA
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  3. OSAMU GOTOH
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  4. MITSURU TAKANAMI
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WADA, A., TACHIBANA, H., GOTOH, O. et al. Long range homogeneity of physical stability in double-stranded DNA. Nature 263, 439–440 (1976). https://doi.org/10.1038/263439a0

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  • DOI: https://doi.org/10.1038/263439a0

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