Abstract
THE triethylammonium salt of the dinucleoside phosphate, thymidylyl-3′, 5′-deoxyadenosine (TpdA) forms helical structures when aqueous solutions are allowed to evaporate1. There are some similarities between the X-ray diffraction patterns from TpdA and those from poly(dA-dT)–poly(dA-dT), and we originally thought that the structures might be similar1. But when the structure for poly(dA-dT)–poly(dA-dT) was proposed2 it was apparent that the TpdA structure was not of the same kind. This, together with the fact that we had obtained more detailed X-ray diffraction patterns from better oriented TpdA specimens, led us to consider the different molecular model for TpdA which we describe here.
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References
Wilson, H. R., Nature, 251, 735–736 (1974).
Arnott, S., Chandrasekaran, R., Hukins, D. W. L., Smith, P. J. C., and Watts, L., J. molec. Biol., 88, 523–533 (1974).
Hoogsteen, K., Acta Cryst., 16, 907–916 (1963).
Arnott, S., and Slesing, E., J. molec. Biol., 88, 509–521 (1974).
Saenger, W., and Suck, D., Nature, 242, 610–614 (1973).
Young, D. W., Tollin, P., and Wilson, H. R., Nature, 248, 513–514 (1974).
Viswamitra, M. A., and Seshadri, T. P., Nature, 252, 176–177 (1974).
Langridge, R., et al., J. molec. Biol., 2, 38–64 (1960).
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WILSON, H., AL-MUKHTAR, J. Structure of thymidylyl-3′, 5′-deoxyadenosine. Nature 263, 171–172 (1976). https://doi.org/10.1038/263171a0
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DOI: https://doi.org/10.1038/263171a0
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