Abstract
IN addition to the axons which project to the nucleus caudatus1,2, the dopamine (DA)-containing perikarya of the substantia nigra have extensive dendritic processes. These dendrites, observed after Golgi staining3–5 and by electron microscopy3,4, contain relatively large amounts of DA—revealed by histofluorescence6—and vesicle–like structures4. The DA seems to be stored in reserpine–sensitive structures6. The question has arisen whether DA can be released from the dendritic processes, as well as from nerve terminals of the nucleus caudatus7,8. Our investigation of the metabolism of released DA suggests that it can.
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References
Ungerstedt, U., Acta physiol. scand., Suppl., 367, 1–48 (1971).
Lindvall, O., and Björklund, A., Acta physiol. scand. Suppl., 412, 1–48 (1974).
Rinvik, E., and Grofova, I., Expl Brain Res., 11, 229–248 (1970).
Hajdu, F., Hassler, R., and Bak, I. J., Z. Zellforschung, 146, 207–221 (1973).
Cajal, S., Ramon, Y., Histologie du Système Nerveux de l'Homme et des Vertébrés, 2, 275–278 (Cousejo Superior de Investigaciones Cientificas, Inst. Ramon y Cajal, Madrid, 1955).
Björklund, A., and Lindvall, O., Brain Res., 83, 531–537 (1975).
McLennan, H., J. Physiol., Lond., 174, 152–161 (1964).
Korf, J., Grasdijk, L., and Westerink, B. H. C., J. Neurochem. (in the press).
Westerink, B. H. C., and Korf, J., Eur. J. Pharmac. (in the press).
Roth, R. H., Walter, J. R., and Aghajanian, G. K., Biochem. Pharmac.,Suppl., 457–464 (1974).
Dahlström, A., and Fuxe, K., Acta physiol. scand., 62, Suppl., 232, 1–55 (1964).
Von Voigtlander, P. F., and Moore, K. E., Neuropharmacology, 10, 733–741 (1971).
Westerink, B. H. C., and Korf, J., Eur. J. Pharmac., 33, 31–40 (1975).
Westerink, B. H. C., and Korf, J., Eur. J. Pharmac. (in the press).
Bunney, B.S., and Aghajanian, G. K., Biochem. Pharmac., Suppl., 792–797 (1974).
Groves, P. M., Wilson, C. J., Young, S. J., and Rebec, G. V., Science, 190, 522–529 (1975).
Stell, W. K., in Handbook of Sensory Physiology, 7, Part 2, Physiology of Photoreceptor Organs (edit. by Fuortes, M. G. F.), 111–213 (Springer, Berlin, Heidelberg, New York, 1972).
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KORF, J., ZIELEMAN, M. & WESTERINK, B. Dopamine release in substantia nigra?. Nature 260, 257–258 (1976). https://doi.org/10.1038/260257a0
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DOI: https://doi.org/10.1038/260257a0
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