Abstract
IN sympathetic ganglia and adrenal medulla, the augmented release of acetylcholine from preganglionic sympathetic neurones can lead to prolonged changes in the activity of tyrosine hydroxylase (TH), the enzyme catalysing the rate-limiting step in the biosynthesis of catecholamines1,2. The trans-synaptically mediated increase in TH activity is due to excitation of cholinergic receptors3–5, occurs after a latency of many hours to days, remains elevated up to weeks and is attributable entirely to increased accumulation of TH enzyme molecules; it therefore represents induction of the enzyme.
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LEWANDER, T., JOH, T. & REIS, D. Prolonged activation of tyrosine hydroxylase in noradrenergic neurones of rat brain by cholinergic stimulation. Nature 258, 440–441 (1975). https://doi.org/10.1038/258440a0
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DOI: https://doi.org/10.1038/258440a0
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