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Positive control of cyclic AMP on mesenchymal factor controlled DNA synthesis in embryonic pancreas

Abstract

THERE is increasing evidence that cyclic AMP and/or cyclic GMP are involved in the regulation of a number of metabolic processes including cell proliferation1–13. We report here the results of an investigation testing the effects of cyclic AMP, cyclic GMP and the mesenchymal factor (MF)14–17 on the stimulation of DNA synthesis in embryonic epithelia in organ culture.

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References

  1. Ryan, W. L., and Heidrick, M. L., Science, 162, 1484–1485 (1968).

    Article  ADS  CAS  Google Scholar 

  2. Frank, W., Expl Cell Res., 71, 238–241 (1972).

  3. Wahrmann, J. P., Winand, R., and Luzzati, D., Nature new Biol., 245, 112–113 (1973).

    Article  CAS  Google Scholar 

  4. Johnson, G. S., and Pastan, I., J. natn. Cancer Inst., 48, 1377–13 (1972).

  5. Hovi, T., and Vaheri, A., Nature new Biol., 245, 175–176 (1973).

    Article  CAS  Google Scholar 

  6. Burger, M. M., Bombik, B. M., Breckenridge, B. McL., and Sheppard, J. R., Nature new Biol., 239, 161–163 (1972).

    Article  CAS  Google Scholar 

  7. Otten, J., Johnson, G. S., and Pastan, I., Biochem. biophys. Res. Commun., 44, 1192–1198 (1971).

    Article  CAS  Google Scholar 

  8. Johnson, G. S., and Pastan, I., Nature new Biol., 236, 247–249 (1972).

    Article  CAS  Google Scholar 

  9. Rudland, P. S., Seeley, M., and Seifert, W., Nature, 251, 417–419 (1974).

    Article  ADS  CAS  Google Scholar 

  10. Hadden, J. W., Hadden, E. M., Haddox, M. K., and Goldberg, N. D., Proc. natn. Acad. Sci. U.S.A., 69, 0324–3027 (1972).

  11. Seifert, W. E., and Rudland, P. S., Nature, 248, 138–140 (1974).

    Article  ADS  CAS  Google Scholar 

  12. Rudland, P. S., Gospodarowicz, D., and Seifert, W., Nature, 250, 741–742 (1974).

    Article  ADS  CAS  Google Scholar 

  13. Weinstein, Y., Chambers, D. A., Bourne, H. R., and Melmon, K. L., Nature, 251, 352–353 (1974).

    Article  ADS  CAS  Google Scholar 

  14. Rutter, W. J., Wessells, N. K., and Grobstein, C., Natn. Cancer Inst. Monogr., 13, 51–65 (1964).

    CAS  Google Scholar 

  15. Ronzio, R. A., and Rutter, W. J., Devl Biol., 30, 307–320 (1973).

    Article  CAS  Google Scholar 

  16. Levine, S., Pictet, R., and Rutter, W. J., Nature new Biol., 246, 49–52 (1973).

    Article  CAS  Google Scholar 

  17. Pictet, R., Filosa, S., Phelps, P., and Rutter, W. J., in Extracellular Matrix Influences on Gene Expression (edit. by Greulich, R., and Slavkin, H. C.), 531–540 (Academic, New York, 1975).

    Book  Google Scholar 

  18. Grobstein, C., Natn. Cancer Res. Inst. Monogr., 76, 273–282 (1964).

    Google Scholar 

  19. Wolff, E., Curr. Top. Dev. Biol., 3, 65–94 (1968).

    Article  CAS  Google Scholar 

  20. Rasmussen, H., Goodman, D. B. P., and Tenenhouse, A., Crit. Rev. Biochem., 1, 95–150 (1972).

    Article  CAS  Google Scholar 

  21. Reed, P. W., and Lardy, H. A., J. biol. Chem., 247, 6970–6977 (1972).

    CAS  Google Scholar 

  22. Prince, W. T., Rasmussen, H., and Berridge, M. J., Biochim. biophys. Acta, 329, 98–107 (1973).

    Article  CAS  Google Scholar 

  23. Selinger, Z., Eimerl, S., and Scharm, M., Proc. natn. Acad. Sci. U.S.A., 71, 128–131 (1974).

    Article  ADS  CAS  Google Scholar 

  24. Charles, M. A., Lawecki, J., Pictet, R., and Grodsky, G. M., J. biol. Chem. (in the press).

  25. Cuatrecasas, P., Proc. natn. Acad. Sci. U.S.A., 63, 450–457 (1969).

    Article  ADS  CAS  Google Scholar 

  26. Krug, R., Desbuguois, B., and Cuatrecasas, P., Nature new Biol., 234, 268–270 (1970).

    Article  Google Scholar 

  27. Schimmer, B P, Ueda, K., and Sato, G. H., Biochem. biophys. Res. Commun., 32, 806–810 (1968).

    Article  CAS  Google Scholar 

  28. Hecht, J. P., et al., FEBS Lett., 20, 83–86 (1972).

    Article  ADS  CAS  Google Scholar 

  29. Luft, J. H., J. biophys. biochem. Cytol., 9, 409–411 (1961).

    Article  CAS  Google Scholar 

  30. Caro, L. G., and van Tubergen, R. P., J. Cell Biol., 15, 173–188 (1962).

    Article  CAS  Google Scholar 

  31. Pictet, R., Clark, W. R., Williams, R. H., and Rutter, W. J., Devl Biol., 29, 436–467 (1972).

    Article  CAS  Google Scholar 

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FILOSA, S., PICTET, R. & RUTTER, W. Positive control of cyclic AMP on mesenchymal factor controlled DNA synthesis in embryonic pancreas. Nature 257, 702–705 (1975). https://doi.org/10.1038/257702a0

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