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Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse

Nature volume 256, pages 644–646 (1975)Cite this article

Abstract

SEVERAL cases of allelic variation have been reported in the mouse that are presumably determined by genes for the variable region of the heavy chain of immunoglobulins1–8. These genes control qualitative and/or quantitative differences in the immune response to particular antigens, and exhibit close linkage to the cluster of genes (Ig-1, Ig-2, Ig-3, Ig-4) that determine the allotypic differences residing in the constant portion of the heavy chains of several immunoglobulin classes9–11. (No recombinants have been observed among the latter in over 2,000 backcross mice.) Significantly, several presumptive recombinants have been recovered that seem to separate some variable region genes from the allotype loci, and some variable region genes from each other1,12. Outside genetic markers would be very valuable in identifying and interpreting these presumptive recombinants. Unfortunately, efforts to place the heavy chain allotype locus in the mouse linkage map have been unsuccessful9,10,13. We report here the discovery of close linkage between Ig-1 and the serum prealbumin locus of the mouse.

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Authors and Affiliations

  1. The Jackson Laboratory Bar Harbor, Maine, 04609

    B. A. TAYLOR, D. W. BAILEY & M. CHERRY

  2. Institute for Cancer Research Philadelphia, Pennsylvania, 19111

    R. RIBLET & M. WEIGERT

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  1. B. A. TAYLOR
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  2. D. W. BAILEY
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TAYLOR, B., BAILEY, D., CHERRY, M. et al. Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse. Nature 256, 644–646 (1975). https://doi.org/10.1038/256644a0

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