Abstract
THYROTROPIN-RELEASING hormone (TRH) (pyroglutamyl-histidyl-proline-amide) has been reported to ameliorate mental depression1,2. The mechanism of action of the tripeptide in this condition is unknown. It may be connected with changes in the activity of noradrenergic or 5-hydroxytryptaminergic neurons which are thought to be involved in depressive states3,4. Therefore, we have investigated the action of TRH on the turnover of biogenic amines in rat brain.
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References
Kastin, A. J., Ehrensing, R. H., Schalch, D. S., and Anderson, M. S., Lancet, ii, 740 (1972).
Prange, jun., A. J., Wilson, I. C., Lara, P. P., and Alltop, L. B., Lancet, ii, 999 (1972).
Schildkraut, J. J., Kopin, I. J., Schanberg, S. M., and Durell, J., Pharmakopsychiat. Neuro-Psychopharmak, 1, 69 (1968).
Coppen, A., Psychiat. Neurol. Neurochir., 72, 173 (1969).
Glowinski, J., and Iversen, L. L., J. Neurochem., 13, 655 (1966).
Laverty, R., and Taylor, K. M., Anal. Biochem., 22, 269 (1968).
Snyder, S. H., Axelrod, J., and Zweig, M., Biochem. Pharmacol., 14, 831 (1965).
Meek, J. L., and Neff, N. H., Br. J. Pharmac., 45, 435 (1972).
Andén, N.-E., Roos, B.-E., and Werdinius, B., Life Sci., 7, 448 (1963).
Giacalone, E., and Valzelli, L., J. Neurochem., 13, 1265 (1966).
Hayden, J. F., Johnson, L. R., and Maickel, R. P., Life Sci., 5, 1509 (1966).
Anton, A., and Sayre, D. F., J. Pharmac. exp. Ther., 138, 360 (1962).
Bertler, A., Carlsson, A., and Rosengren, E., Acta physiol. scand., 44, 273 (1958).
Murphy, B. E. P., and Jachan, D., J. Lab. clin. Med., 66, 161 (1965).
Caesar, P. M., and Sharman, D. F., Br. J. Pharmac., 44, 340P (1972).
Meek, J. L., and Neff, N. H., J. Pharmac. exp. Ther., 181, 457 (1972).
Plotnikoff, N. P., Prange, A. J., Breese, G. R., Anderson, M. S., and Wilson, I. C., Science, N. Y. 178, 417 (1972).
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KELLER, H., BARTHOLINI, G. & PLETSCHER, A. Enhancement of cerebral noradrenaline turnover by thyrotropin-releasing hormone. Nature 248, 528–529 (1974). https://doi.org/10.1038/248528a0
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DOI: https://doi.org/10.1038/248528a0
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