Abstract
PHALLOIDIN (PHD) is a toxic cyclopeptide in Amanita phalloides1,2. Rats and mice injected with this toxin die in 2–4 h from hepatic necrosis. Dilatation of the endoplasmic reticulum (ER) with the appearance of very large vacuoles are the first ultrastructural changes in hepatocytes3,4. The first biochemical lesion produced by PHD is unknown2. Hepatocytes are the only cells damaged by PHD in mice and rats5,6; Heart fibroblasts7 and bovine kidney cells5 cultured in vitro are not affected by this toxin.
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BARBANTI-BRODANO, G., DERENZINI, M. & FIUME, L. Toxic action of a phalloidin-albumin conjugate on cells with a high protein uptake. Nature 248, 63–65 (1974). https://doi.org/10.1038/248063a0
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DOI: https://doi.org/10.1038/248063a0
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