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Dietary Enhancement of Intestinal Carcinogenesis by Dimethylhydrazine in Rats

Nature volume 246, pages 491–492 (1973)Cite this article

Abstract

WHILE investigating the effect of marginal lipotrope deficiency in rats on chemical carcinogenesis, we have found an effect in an organ other than liver. We have already reported the enhancement of aflatoxin B1-induction of hepatocarcinoma by lipotrope deficiency and recently found that N-nitrosodiethylamine and N-nitrosodibutylamine induce hepatocarcinoma earlier and in higher incidence in lipotrope-deficient rats than in normal rats1,8. In the study reported here, induction of tumours of large and small intestine by symmetrical dimethylhydrazine (DMH) was examined in normal or lipotrope-deficient rats and was found to be enhanced in deficient rats.

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Authors and Affiliations

  1. Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139

    ADRIANNE E. ROGERS & PAUL M. NEWBERNE

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  1. ADRIANNE E. ROGERS
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  2. PAUL M. NEWBERNE
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ROGERS, A., NEWBERNE, P. Dietary Enhancement of Intestinal Carcinogenesis by Dimethylhydrazine in Rats. Nature 246, 491–492 (1973). https://doi.org/10.1038/246491a0

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