Abstract
VARIOUS mechanisms have been proposed for the action of hormones in cells. One is a cytoplasmic mechanism involving mitochondria1,2; a second implies that cytoplasmic protein receptors act as sites3 for the hormone action; a third proposes that the nuclei act as a primary site for hormone action4,5. We now demonstrate that cortisol, when used for brief periods and in physiological doses, increased the RNA polymerase activity of rat liver mitochondria. In these conditions nuclear RNA synthesis was not affected. Hormone treatment for longer periods or treatment with large doses for short time periods increased the nuclear RNA polymerase activity and suppressed the mitochondrial enzyme.
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References
Sokoloff, L., Roberts, P. A., Januska, M. M., and Kline, J. E., Proc. US Nat. Acad. Sci., 60, 652 (1968).
De Venuto, F., Kelleher, P. C., and Westphal, U., Biochim. Biophys. Acta, 63, 434 (1962).
Jensen, E. V., Suzuki, T., Kawashima, T., Stumpf, W. E., Jungblut, P. W., and DeSombre, E. R., Proc. US Nat. Acad. Sci., 59, 632 (1968).
Tata, J. R., Prog. Nucleic Acid Res., 5, 191 (1966).
Karlson, P., and Sekeris, C. E., Acta Endocrinol., 53, 505 (1966).
Schneider, W. C., J. Biol. Chem., 176, 259 (1948).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).
Chamberlin, M., and Berg, P., Proc. US Nat. Acad. Sci., 48, 81 (1962).
Bollum, F. J., J. Biol. Chem., 234, 2733 (1959).
Mansour, A. M., Acta Endocrinol., 57, 465 (1968).
Beato, M., Homoki, J., and Sekeris, C. E., Exp. Cell Res., 55, 107 (1969).
Noteboom, W. D., and Gorski, J., Arch. Biochem. Biophys., 111, 559 (1965).
Wichmam, K., Acta Endocrinol., 55, suppl. 116 (1967).
Demisch, K., Birkelbach, P., Ammedick, U., and Staib, W., Acta Endocrinol., 62, 147 (1969).
Litwack, G., Sears, M. L., and Diamondstone, T. L., J. Biol. Chem., 238, 302 (1963).
Morris, D. J., and Barnes, jun., F. W., Biochim. Biophys. Acta, 136, 67 (1967).
Steggles, A. E., and King, R. J. B., J. Endocrinol., 38, 25 (1967).
Brunkhorst, W. K., Biochem. Biophys. Res. Commun., 35, 880 (1969).
Barnabei, O., Romano, B., Di Bitonto, G., Tomasi, V., and Sereni, F., Arch. Biochem. Biophys., 113, 478 (1966).
Lang, N., and Sekeris, C. E., Life Sci., 3, 391 (1966).
Nass, S., Biochim. Biophys. Acta, 145, 60 (1967).
Schultz, S. R., and Nass, S., FEBS Letters, 4, 13 (1969).
Clayton, D. A., and Vinograd, J., Nature, 216, 652 (1967).
Nass, S., Intern. Rev. Cytol., 25, 55 (1969).
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MANSOUR, A., NASS, S. In vivo Cortisol Action on RNA Synthesis in Rat Liver Nuclei and Mitochondria. Nature 228, 665–667 (1970). https://doi.org/10.1038/228665a0
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DOI: https://doi.org/10.1038/228665a0
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