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The S1 Factor in Peptide Chain Elongation

Nature volume 227, pages 34–38 (1970)Cite this article

Abstract

Aminoacyl-tRNA becomes attached to the ribosome as part of an S3 factor–GTP–aminoacyl-tRNA complex. GTP is then cleaved and an S3 factor–GDP complex is released. The S1 factor promotes the re-formation of the S3 factor–GTP–aminoacyl-tRNA complex from the S3 factor–GDP complex, aminoacyl-tRNA and GTP.

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References

  1. Lipmann, F., Science, 164, 1024 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Lengyel, P., and Söl, D., Bact. Rev., 33, 264 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Skoultchi, A., Ono, Y., Moon, H. M., and Lengyel, P., Proc. US Nat. Acad. Sci., 60, 675 (1968).

    Article  ADS  CAS  Google Scholar 

  4. Lucas-Leuard, J., and Lipmann, F., Proc. US Nat. Acad. Sci., 55, 1562 (1966).

    Article  ADS  Google Scholar 

  5. Shorey, R., Ravel, J., Garner, G. W., and Shive, W., J. Biol. Chem., 244, 4555 (1969).

    CAS  PubMed  Google Scholar 

  6. Gordon, J., Proc. US Nat. Acad. Sci., 59, 179 (1968).

    Article  ADS  CAS  Google Scholar 

  7. Ono, Y., Skoultchi, A., Waterson, J., and Lengyel, P., Nature, 223, 697 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Lucas-Lenard, J., and Haenni, A., Proc. US Nat. Acad. Sci., 59, 554 (1968).

    Article  ADS  CAS  Google Scholar 

  9. Skoultchi, A., Ono, Y., Waterson, J., and Lengyel, P., Biochemistry, 9, 508 (1970).

    Article  CAS  PubMed  Google Scholar 

  10. Lucas-Lenard, J., and Lipmann, F., Proc. US Nat. Acad. Sci., 57, 1050 (1967).

    Article  ADS  CAS  Google Scholar 

  11. Ono, Y., Skoultchi, A., Waterson, J., and Lengyel, P., Nature, 222, 645 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Gordon, J., J. Biol. Chem., 244, 5680 (1969).

    CAS  PubMed  Google Scholar 

  13. Haenni, A., and Lenard, J. L., Proc. US Nat. Acad. Sci., 61, 1363 (1968).

    Article  ADS  CAS  Google Scholar 

  14. Kuriki, Y., and Kaji, A., Proc. US Nat. Acad. Sci., 61, 1399 (1968).

    Article  ADS  CAS  Google Scholar 

  15. Lucas-Lenard, J., and Haenni, A., Proc. US Nat. Acad. Sci., 63, 93 (1969).

    Article  ADS  CAS  Google Scholar 

  16. Traut, R., and Monro, R., J. Mol. Biol., 10, 63 (1964).

    Article  CAS  PubMed  Google Scholar 

  17. Brot, N., Ertel, R., and Weissbach, H., Biochem. Biophys. Res. Commun., 31, 563 (1968).

    Article  CAS  PubMed  Google Scholar 

  18. Ertel, R., Redfield, B., Brot, N., and Weissbach, H., Arch. Biochem. Biophys., 128, 331 (1968).

    Article  CAS  PubMed  Google Scholar 

  19. Pestka, S., Proc. US Nat. Acad. Sci., 61, 726 (1968).

    Article  ADS  CAS  Google Scholar 

  20. Erbe, R., Nau, M., and Leder, P., J. Mol. Biol., 39, 441 (1969).

    Article  CAS  PubMed  Google Scholar 

  21. Ertel, R., Brot, N., Redfield, B., Allende, J., and Weissbach, H., Proc. US Nat. Acad. Sci., 59, 861 (1968).

    Article  ADS  CAS  Google Scholar 

  22. Ono, Y., Skoultchi, A., Klein, A., and Lengyel, P., Nature, 220, 1304 (1968).

    Article  ADS  CAS  PubMed  Google Scholar 

  23. Weissbach, H., Miller, O., and Hachmann, J. (in the press).

  24. Calendar, R., and Berg, P., Biochemistry, 5, 1681 (1966).

    Article  CAS  PubMed  Google Scholar 

  25. Lowry, O., Bosebrough, N., Farr, A., and Randall, R., J. Biol. Chem., 193, 265 (1951).

    CAS  PubMed  Google Scholar 

  26. Bray, G., Anal. Biochem., 1, 279 (1960).

    Article  CAS  Google Scholar 

  27. Haenni, A., and Chapeville, F., Biochim. Biophys. Acta, 114, 135 (1936).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut

    J. WATERSON, G. BEAUD & P. LENGYEL

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  1. J. WATERSON
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  2. G. BEAUD
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  3. P. LENGYEL
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WATERSON, J., BEAUD, G. & LENGYEL, P. The S1 Factor in Peptide Chain Elongation. Nature 227, 34–38 (1970). https://doi.org/10.1038/227034a0

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