Abstract
WE have reported that short-term (24 h) exposure of human lymphocyte cultures to phytohaemagglutinin (PHA) results in the conversion of 90 per cent or more of the small lymphocytes to “blastlike” forms. Subsequently, the cultures revert to cells which resemble the original unstimulated small lymphocytes, both morphologically and metabolically, but remain fully reactive to renewed PHA stimulation1. In this report, we offer evidence that, in the 24 h PHA-stimulated cultures, most lymphocytes become blastoid but do not divide; instead, they return to their original form by 9 or 10 days after stimulation.
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POLGAR, P., KIBRICK, S. Origin of Small Lymphocytes following Blastogenesis induced by Short-term PHA Stimulation. Nature 225, 857–858 (1970). https://doi.org/10.1038/225857a0
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DOI: https://doi.org/10.1038/225857a0
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