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Genetic Mapping of an Endonuclease synthesized by Bacteriophage Lambda

Nature volume 223, pages 852–853 (1969)Cite this article

Abstract

THE synthesis of bacteriophage λ DNA in host cells requires normal functioning of the bacteriophage genes O and P. These genes seem to be uniquely concerned with λ DNA replication because a mutation in either the O or P cistron will completely prevent λ DNA synthesis1. None of the other λ genes so far investigated have this profound effect on the phage DNA replication2. The mechanism by which cistrons O and P control λ DNA synthesis is unknown, but here we report that both of these genes are required for the appearance of an endonuclease specified by λ.

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Authors and Affiliations

  1. Department of Biochemistry, Emory University, Atlanta, Georgia

    ROBERT C. SHUSTER

  2. Roche Institute of Molecular Biology, Nutley, New Jersey

    ARTHUR WEISSBACH

Authors
  1. ROBERT C. SHUSTER
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  2. ARTHUR WEISSBACH
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SHUSTER, R., WEISSBACH, A. Genetic Mapping of an Endonuclease synthesized by Bacteriophage Lambda. Nature 223, 852–853 (1969). https://doi.org/10.1038/223852a0

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