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Origin of the Genetic Code

Nature volume 223, pages 799–804 (1969)Cite this article

Abstract

A molecular model of the interaction between mononucleotides and polyamino-acids predicts the glycine codon GGG, and suggests RNA evolved before DNA.

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References

  1. Watson, J. D., and Crick, F. H. C., Nature, 171, 737 (1953).

    Article  ADS  CAS  Google Scholar 

  2. Woese, C. R., et al., Proc. US Nat. Acad. Sci., 55, 966 (1966).

    Article  ADS  CAS  Google Scholar 

  3. Woese, C. R., Proc. US Nat. Acad. Sci., 59, 110 (1968).

    Article  ADS  CAS  Google Scholar 

  4. Wagner, K. G., and Arav, R., Biochem., 7, 1771 (1968).

    Article  CAS  Google Scholar 

  5. Brahms, J., Michelson, A. M., and Van Holde, K. E., J. Mol. Biol., 15, 467 (1966).

    Article  CAS  Google Scholar 

  6. Leng, M., and Felsenfeld, G., J. Mol. Biol., 15, 455 (1966).

    Article  CAS  Google Scholar 

  7. Pachon, F., and Michelson, A. M., Proc. US Nat. Acad. Sci., 53, 1425 (1965).

    Article  ADS  Google Scholar 

  8. Schweitzer, M. P., et al., J. Amer. Chem. Soc., 90, 1042 (1968).

    Article  Google Scholar 

  9. Pelc, S. R., Nature, 207, 597 (1965).

    Article  ADS  CAS  Google Scholar 

  10. Pelc, S. R., and Welton, G. E., Nature, 209, 868 (1966).

    Article  ADS  CAS  Google Scholar 

  11. DeVoe, H., and Tinoco, I., J. Mol. Biol., 4, 500 (1962).

    Article  CAS  Google Scholar 

Download references

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Author notes

  1. JAMES C. LACEY jun.

    Present address: Institute of Molecular Evolution, University of Miami, Coral Gables, Florida, 33134

Authors and Affiliations

  1. Laboratory of Molecular Biology, University of Alabama in Birmingham, Birmingham, Alabama, 35233

    JAMES C. LACEY jun. & KENNETH M. PRUITT

Authors
  1. JAMES C. LACEY jun.
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  2. KENNETH M. PRUITT
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LACEY, J., PRUITT, K. Origin of the Genetic Code. Nature 223, 799–804 (1969). https://doi.org/10.1038/223799a0

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