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Molecular Pathology of Human Haemoglobin

Nature volume 219, pages 902–909 (1968)Cite this article

An Erratum to this article was published on 05 October 1968

Abstract

The haemoglobin molecule is insensitive to replacements of most amino-acid residues on its surface, but extremely sensitive to even quite small alterations of internal non-polar contacts, especially those near the haems. Replacements at the contacts between α and β-subunits affect respiratory function.

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Author information

Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Cambridge

    M. F. PERUTZ

  2. MRC Abnormal Haemoglobin Research Unit, Department of Biochemistry, University of Cambridge,

    H. LEHMANN

Authors
  1. M. F. PERUTZ
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  2. H. LEHMANN
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PERUTZ, M., LEHMANN, H. Molecular Pathology of Human Haemoglobin. Nature 219, 902–909 (1968). https://doi.org/10.1038/219902a0

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