Abstract
THE abolition of the complement binding activity of IgG globulin molecules by exposure to low pHs (refs. 1 and 2) has prompted us to investigate the effect of acid-treated anti-lymphocytic IgG on humoral and cell mediated immune responses in the rat. These studies form part of a larger investigation aimed at elucidating the mode of action of anti-lymphocytic serum and developing less toxic products for therapeutic use.
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ANDERSON, N., JAMES, K. & WOODRUFF, M. Effect of Acid Treatment on the Immunosuppressive Properties of Anti-lymphocytic IgG. Nature 218, 771–773 (1968). https://doi.org/10.1038/218771a0
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DOI: https://doi.org/10.1038/218771a0
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