Abstract
THIS communication describes an investigation of the effects of chloroquine treatment on the ultrastructure of Plasmodium berghei in the mouse and rat, and of P. cynomolgi in the rhesus monkey. Chloroquine was given to the animals intraperitoneally in doses which produced a detectable reduction in parasitaemia on the day after administration (50, 95 and 17.5 mg/kg respectively). Blood samples were fixed for electron microscopy (2.5 per cent to 5 per cent glutaraldehyde followed by 1 per cent osmic acid) before and after injection of the drug.
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WARHURST, D., HOCKLEY, D. Mode of Action of Chloroquine on Plasmodium berghei and P. cynomolgi. Nature 214, 935–936 (1967). https://doi.org/10.1038/214935a0
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DOI: https://doi.org/10.1038/214935a0
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