Abstract
ONE of the most suitable radioisotopic diagnostic methods for demonstrating pathologically altered tissue is scanning with the use of a “hot” area. In practice, however, this method is only of limited use. As shown previously, some tetracycline antibiotics accumulate and are retained in injured tissues, which include ischaemically altered myocardium, the striated muscles and the kidneys1,2. Some iodinated derivatives labelled with iodine-131 which were expected to be suitable for scanning pathological foci were prepared—N-1-3,5-dimethyl-4-iodopyrazolyl-methyl-tetracycline-131 I (derivative I) and tetracycline monoester of tetraiodophthalic acid-131I (derivative II)3. In addition to these we also prepared several hydroxymercuri-derivatives from fluorescein derivatives: hydroxymercuri-fluorescein-197Hg,-203Hg (derivative III), hydromexicuri-2,7-dibromfluorescein-197Hg,-203Hg (derivative IV), hydroxymercuri-4,5-dibromfluorescein-197Hg,-203Hg (derivative V), and bis-hydroxymercurifluorescein-197Hg or -203Hg (derivative VI)4.
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MÁLEK, P., RATUSKÝ, J., VAVREJN, B. et al. Ischaemia Detecting Radioactive Substances for Scanning Cardiac and Skeletal Muscle. Nature 214, 1130–1131 (1967). https://doi.org/10.1038/2141130a0
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DOI: https://doi.org/10.1038/2141130a0
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