Abstract
NUMEROUS investigators1–5 have shown that the administration of narcotic drugs to animals causes an increase in the brain acetylcholine-like activity. Most of these authors1–4 believed that the material extractable from such brains was acetylcholine and this was based largely on the results obtained from experiments performed with the parallel bio-assay technique. Hosein and Koh6 and Hosein, Rambaut, Chabrol and Orzeck7 have shown that the method of parallel bio-assay is incapable of identifying acetylcholine in mixtures of substances which possess acetylcholine-like activity. In addition, these latter authors showed that the various test preparations used in the method of parallel bio-assay could not discriminate between mixtures of substances which possessed acetylcholine-like activity, even when non-natural substances were used.
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HOSEIN, E., ORZECK, A. Acetylcholine-like Activity of Acetyl-l-carnityl CoA in the Brains of Narcotized Rats. Nature 210, 731–732 (1966). https://doi.org/10.1038/210731a0
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DOI: https://doi.org/10.1038/210731a0
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