Abstract
SPONTANEOUSLY occurring carcinoma of the glandular stomach in the rat is exceedingly rare. In a large series Bullock and Curtis1 reported a single case, while Stewart et al.2 in a review of the literature failed to find a convincing example of adenocarcinoma of the stomach in the rat. Experimentally, Hare et al.3 produced a low incidence of glandular carcinoma on intramural injection of the carcinogenic polycyclic hydrocarbons. The same substances on feeding failed to induce carcinoma of the stomach. Stewart et al.2 have since demonstrated that oral administration of N,N′ 2,7-fluorenylenebisacetamide will induce a low incidence of stomach adenocarcinoma (4 in 47 rats), and Schoental4 has reported the induction of malignant adenocarcinoma with N-nitroso-N-methylurethane (NMU). It is the purpose of this communication to describe the incidence of carcinoma of the glandular stomach observed in a series of experiments in which the toxicity of groundnut meal containing aflatoxin was investigated.
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Stewart, H. L., Snell, K. C., Morris, H. P., Wagner, B. P., and Ray, F. E., Nat. Cancer Inst. Monogr., 5, 105 (1961).
Hare, W. V., Stewart, H. L., Bennett, J. G., and Lorenze, E., J. Nat. Cancer Inst., 12, 1019 (1952).
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BUTLER, W., BARNES, J. Carcinoma of the Glandular Stomach in Rats given Diets containing Aflatoxin. Nature 209, 90 (1966). https://doi.org/10.1038/209090a0
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DOI: https://doi.org/10.1038/209090a0
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