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Stimulation of Mast Cell Production in Lymph Nodes of the Rat by Pyrrolizidine Alkaloids

Nature volume 207, pages 1305–1306 (1965)Cite this article

Abstract

MAST cells are known to increase in some tissues under certain conditions often associated with an immunological component. Well-known examples are in the skin in the vicinity of induced epitheliomas in mice1 and associated with proliferative changes in the thymus of NZB mice2. In lymph nodes, where under normal conditions mast cells occur in small numbers only, Miller3 observed an increase in mast cell numbers after injection of Salmonella antigens, and Takeoka et al.4 noted a significant increase in mast cells in the lungs and mediastinal lymph nodes in rats being fed seeds of Crotalaria spectabilis or the pyrrolizidine alkaloid, monocrotaline, isolated from this plant.

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References

  1. Bloom, G. D., Ann. N.Y. Acad. Sci., 103, 53 (1963).

    Article  ADS  CAS  Google Scholar 

  2. Burnet, F. M., J. Path. Bact., 89, 271 (1965).

    Article  CAS  Google Scholar 

  3. Miller, J. J., III (personal communication).

  4. Takeoka, O., Angevine, D. M., and Lalich, J. J., Amer. J. Path., 40, 545 (1962).

    CAS  PubMed  Google Scholar 

  5. Culvenor, C. C. J., Dann, A. T., and Dick, A. T., Nature, 195, 570 (1962).

    Article  ADS  CAS  Google Scholar 

  6. Culvenor, C. C. J., Drummond, L. J., and Price, J. R., Austral. J. Chem., 7, 277 (1954).

    Article  CAS  Google Scholar 

  7. Culvenor, C. C. J., Austral. J. Chem., 7, 287 (1954).

    Article  CAS  Google Scholar 

  8. Bull, L. B., Dick, A. T., and McKenzie, J. S., J. Path. Bact., 75, 19 (1958).

    Article  Google Scholar 

  9. Bull, L. B., and Dick, A. T., J. Path. Bact., 78, 483 (1959).

    Article  CAS  Google Scholar 

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Author notes

  1. E. DIENER: Supported by a Roche fellowship.

Authors and Affiliations

  1. Walter and Eliza Hall Institute for Medical Research, Royal Melbourne Hospital, Australia

    E. DIENER

  2. C.S.I.R.O. Division of Animal Health, Parkville, N.2, Victoria, Australia

    A. T. DICK

Authors
  1. E. DIENER
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  2. A. T. DICK
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DIENER, E., DICK, A. Stimulation of Mast Cell Production in Lymph Nodes of the Rat by Pyrrolizidine Alkaloids. Nature 207, 1305–1306 (1965). https://doi.org/10.1038/2071305b0

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