Abstract
IT is generally agreed that protein and enzyme syntheses are depressed in the liver of ethionine-treated animals and that the mature female preferentially exhibits this diminution1,2. We were surprised, therefore (Fig. 1), to find a rise (200–300 per cent) of liver glueose-6-phosphate dehydrogenase activity in both sexes of ethionine-treated rats. On the other hand, 6-phosphogluconate dehydrogenase, which is the next enzyme in the shunt pathway sequence, is unaffected and pyruvate kinase of the Krebs cycle undergoes a decrease (50 per cent) in the liver of the female but not the male rat. In animals receiving both methionine and ethionine, no alterations from normal occurred. Accordingly, these diverse effects on enzyme activity of ethionine are now being reported to emphasize the complexity of enzyme phenomena in ethionine-treated animals.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Farber, E., Adv. Cancer Res., 7, 383 (1963).
Stekol, J. A., Adv. Enzymol., 25, 369 (1963).
Nigam, V. N., Macdonald, H. L., and Cantero, A., Cancer Res., 22, 131 (1962).
Fitch, W. M., Hill, R., and Chaikoff, I. L., J. Biol. Chem., 234, 1048 (1959).
Huggins, C., and Yao, F. O., J. Exp. Med., 110, 899 (1959).
Sie, H. G., Fed. Proc., 22, 585 (1963).
Chayen, J., Bitensky, L., Aves, E. K., Jones, G. R., Silcox, A. A., and Cunningham, G. J., Nature, 203, 714 (1962).
Kit, S., Cancer Res., 16, 70 (1956).
Weber, G., and Cantero, A., Cancer Res., 17, 995 (1957).
Weber, G., and Morris, H. P., Cancer Res., 23, 987 (1963).
Farber, E., Shull, K. H., Villa-Trevino, S., Lombardi, B., and Thomas, M., Nature, 203, 34 (1964).
Stekol, J. A., Weiss, S., and Somerville, C., Arch. Biochem. Biophys., 100, 86 (1962).
Turner, M. R., and Reid, E., Nature, 203, 1174 (1964).
Chatagner, F., Nature, 203, 1177 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SIE, HG., HABLANIAN, A. Apparent Paradox in the Effects of Ethionine feeding on the Specific Activities of Rat Liver Glucose-6-phosphate Dehydrogenase and Pyruvate Kinase. Nature 205, 1317–1318 (1965). https://doi.org/10.1038/2051317a0
Issue Date:
DOI: https://doi.org/10.1038/2051317a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
