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Appearance of Fructose-1,6-Diphosphatase in Post-Natal Rat Liver

Nature volume 195, pages 498–499 (1962)Cite this article

Abstract

MANY liver enzymes are known to increase in activity after the birth of mammals1–4, but the biological significance of such changes is often difficult to assess. Mitochondrial enzymes concerned with the metabolism of carbohydrate4 and microsomal enzymes1,2 show especially marked changes in the liver of early post-natal animals, In the rat, sheep, pig and guinea pig, glucose-6-phosphatase, a microsomal enzyme, makes its first appearance at parturition1, This enzyme is an obligatory component of the system for the conversion of liver glycogen to blood glucose, and its rapid appearance at parturition reflects the changed circumstances of the new-born, in that the animal is now obliged to regulate its own blood glucose-levels.

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Authors and Affiliations

  1. Department of Biochemistry, University of Western Australia, Nedlands, Western Australia

    F. J. BALLARD & I. T. OLIVER

Authors
  1. F. J. BALLARD
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  2. I. T. OLIVER
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BALLARD, F., OLIVER, I. Appearance of Fructose-1,6-Diphosphatase in Post-Natal Rat Liver. Nature 195, 498–499 (1962). https://doi.org/10.1038/195498a0

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