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Reversal of Mitomycin c-induced Growth and Division Inhibition in a Species of Erwinia

Abstract

MITOMYCIN c, an anti-tumour agent from culture filtrates of Streptomyces caespitosus, is effective against both Gram-positive and negative bacteria, and is bacteriocidal to growing and non-growing bacteria1. It is an extremely potent inhibitor of growth and cell division of an Erwinia species, using a synthetic medium2 normally supporting excellent growth.

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GRULA, M., GRULA, E. Reversal of Mitomycin c-induced Growth and Division Inhibition in a Species of Erwinia. Nature 195, 1126–1127 (1962). https://doi.org/10.1038/1951126a0

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