Abstract
THE enterohepatic circulation of bile pigment has been the subject of protracted debate. Recirculation of bilirubin, and its bacterial reduction products, the urobilinoids, has been postulated and denied1. The availability of bilirubin labelled with carbon-14 in this Laboratory2 has obviated many of the problems previously inherent in the study of bilirubin metabolism. The following is a preliminary report of investigations of the enterohepatic circulation of bilirubin.
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Broun, G. O., McMaster, P. D., and Rous, P., J. Exp. Med., 37, 699 (1923). McMaster, P. D., and Elman, R., J. Exp. Med., 41, 719 (1925). Baumgartel, T., Arch. inn. Med., 1, 40 (1949). Watson, C. J., in Handbook of Hematology, edit. by H. Downey (Paul B. Hoeber, Inc., New York, 1938). With, K. T., Biologie der Gallenfarbstoffe (Georg Thieme Verlag, Stuttgart, 1960).
Ostrow, J. D., Hammaker, L., and Schmid, R., J. Clin. Invest., 40, 1442 (1961).
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LESTER, R., OSTROW, J. & SCHMID, R. Enterohepatic Circulation of Bilirubin. Nature 192, 372 (1961). https://doi.org/10.1038/192372a0
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DOI: https://doi.org/10.1038/192372a0
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