The Psychotomimetic Properties of 3,4,5-Trimethoxyamphetamine

Abstract

dl-3,4,5-TRIMETHOXYAMPHETAMINE (dl-TMA), first prepared as a homologue of mescaline in 1947 ¹, has remained to a large measure unexplored. A single paper has described its effects in human subjects², demonstrating that the drug allows stroboscope-induced hallucinations at the levels employed, namely, 0.8–2.0 mgm./kgm., orally. In the present work, dl-3,4,5-trimethoxyamphetamine was synthesized by the general method of Ramirez and Burger³ and was chemically identical to that previously described¹. Pharmacological similarity was demonstrated by the administration of between 1.6 and 2.0 mgm./kgm. as the hydrochloride, to three adult male subjects. The responses were found to be parallel in intensity and duration to those described earlier², although the vivid hallucinations reported were not observed.