Abstract
DURING radiobiological work on bacteria it was found by one of us (H. L.) that the effect of ionizing radiation (X-rays) is greatly potentiated if the bacteria are irradiated in a medium in which water is replaced by heavy water1. Thus, for example, with Escherichia coli B and Pseudomonas 6009 the dose-reduction factor was approximately 2, that is, the X-ray dose required to produce a given reduction in the number of colony-forming bacteria on irradiation in deuterium oxide was one half that in water. This effect, however, occurred only if the bacteria were irradiated in presence of oxygen, but not, or only insignificantly, after irradiation under anaerobic conditions.
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References
Laser, H., Int. J. App. Rad. Isotopes, 6, 96 (1959).
Bonhoeffer, K. F., Ergeb. Enzymforschung, 6, 47 (1933).
Shibata, K., and Watanabe, A., Acta Phytochimica, 15, 169 (1949).
Drysdale, G. R., J. Biol. Chem., 234, 2399 (1959).
Slater, E. C., Nature, 172, 975 (1953).
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LASER, H., SLATER, E. Effect of Heavy Water on Respiratory-chain Enzymes. Nature 187, 1115–1117 (1960). https://doi.org/10.1038/1871115a0
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DOI: https://doi.org/10.1038/1871115a0
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