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Swelling of Fresh and Aged Liver Mitochondria as affected by Succinate, Adenine Nucleotides and Thyroxine

Nature volume 186, pages 556–558 (1960)Cite this article

Abstract

IT has been observed previously1 that isolated mitochondria from primary and transplanted hepato-cellular hepatomas, in contrast to their normal counterparts from liver, do not swell to any marked extent in the presence of thyroxine. The increasing evidence2–4 that both the spontaneous and thyroxine-induced swelling of liver mitochondria is actually dependent upon respiration (that is, when no oxi-dizable substrate is added, upon endogenous substrate and co-enzymes) has led us to re-examine the effect of thyroxine on the swelling of the tumour particles now incubated in the presence of succinate.

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Authors and Affiliations

  1. Department of Biochemistry, Antoni van Leeuwenhoek-Huis : The Netherlands Cancer Institute, Amsterdam

    P. EMMELOT, C. J. BOS, P. J. BROMBACHER & I. H. M. REYERS

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  1. P. EMMELOT
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  2. C. J. BOS
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  3. P. J. BROMBACHER
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  4. I. H. M. REYERS
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EMMELOT, P., BOS, C., BROMBACHER, P. et al. Swelling of Fresh and Aged Liver Mitochondria as affected by Succinate, Adenine Nucleotides and Thyroxine. Nature 186, 556–558 (1960). https://doi.org/10.1038/186556b0

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