Abstract
RECENTLY it was postulated that in hæmoglobin and myoglobin the hæm iron is bound to the apoprotein other than through histidine imidazole groups1. This conclusion, which does not appear to be warranted by evidence at present available, is based on the assumption that the pH at which half the hæm is bound to the protein moiety can be identified with the pKL of the binding group. There is no theoretical reason why this should be so.
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FALK, J., PHILLIPS, J. & PERRIN, D. Banding of Hæm to Protein in Hæmoglobin and Myoglobin. Nature 184, 1651–1652 (1959). https://doi.org/10.1038/1841651b0
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DOI: https://doi.org/10.1038/1841651b0
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