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Demonstration of Endogenous Pyrogen in Serum during Systemic Tuberculin Reaction in Rabbits

Nature volume 183, pages 693–694 (1959)Cite this article

Abstract

SUBSTANCES capable of producing fever in normal recipients (the so-called endogenous pyrogens) appear in the serum of experimental animals during fever due to bacterial endotoxin, influenza virus and streptococcal and pneumococcal infections1. Systemic tuberculin reaction is very similar to the effect of bacterial endotoxins2. An attempt has therefore been made to demonstrate the presence of substances with an effect corresponding to that of endogenous pyrogen in the serum of experimental rabbits during systemic tuberculin reaction.

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References

  1. Wood, W. B., Lancet, ii, 53 (1958).

  2. Stetson, Ch. A., J. Exp. Med., 101, 421 (1955).

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  3. Johanovský, J., Folia microbiologica, 4, 101 (1959).

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  4. Stetson, Ch. A., Fed. Proc., 17, 536 (1958).

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Authors and Affiliations

  1. Division of Immunology, Institute of Biology, Czechoslovak Academy of Sciences, Prague

    J. JOHANOVSKÝ

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  1. J. JOHANOVSKÝ
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JOHANOVSKÝ, J. Demonstration of Endogenous Pyrogen in Serum during Systemic Tuberculin Reaction in Rabbits. Nature 183, 693–694 (1959). https://doi.org/10.1038/183693a0

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