Abstract
Jimenez-Diaz, Grande-Covian and De Oya1 have reported recently that dogs in which the vessels of both kidneys were clamped prior to and for ten minutes following the intravenous injection of 100 mgm./kgm. of alloxan failed to develop either the hyperglycæmia or the uræmia of the controls in which the clamping was omitted. On the basis of this experiment they postulated the existence of some factor in the kidney with which the alloxan must come in contact before it can exert its full diabetogenic effect.
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References
Jimenez-Diaz, C., Grande-Covian, F., and De Oya J. C., Nature, 158, 589 (1946).
Goldner, M. G., Bull. N.Y. Acad. Med., 21, 44 (1945).
Somogyi, M., J. Biol. Chem., 160, 61 (1945).
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GOLD, A. Alloxan Diabetes and the Kidney in the Rat. Nature 159, 574–575 (1947). https://doi.org/10.1038/159574b0
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DOI: https://doi.org/10.1038/159574b0
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