Abstract
DURING œstrus in the guinea pig, there is a relative hyperæmia at the antimesometrial border of the bicornate uterus1, and after suitable hormonal treatment similar vascular changes have been induced in the spayed animal2,3. Vaginal cornification, increase in uterine weight, and all the histological features so far recognized of a typical heat response can be elicited in spayed female guinea pigs by a simple administration of œstrogens, but the cyclic vascular change is only displayed after preliminary priming of the animals with small daily injections of œstradiol monobenzoate (0·0005 mgm. for six days) followed by a large daily dose (0·5 mgm.) for two days and a final injection of progesterone (0·2 mgm.). We believe that this antimesometrial hyperæmia in the spayed female guinea pig is not a simple manifestation of œstrogenic activity, but only becomes evident when a hormonal balance approximating to the physiological condition of normal œstrus has been obtained. It is further significant that this antimesometrial hyperæmia is a response of the adult uterus and cannot be induced in the immature guinea pig by either œstrogenic4 or gonadotropic5 stimulation.
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Bacsich, P., and Wyburn, G. M., Trans. Roy. Soc. Edin., 60 79, Pt. i (1940).
Bacsich, P., and Wyburn, G. M., Trans. Roy. Soc. Edin., 60 465, Pt. ii (1941).
Bacsich, P., and Wyburn, G. M., J. Endocrin., 3 401, No. 4 (1944).
Bacsich, P., and Wyburn, G. M., Proc. Roy. Soc. Edin., Sect. B, 61, 188, Pt. ii (1942).
Bacsich, P., and Wyburn, G. M., J. Anal, 77 118, Pt. i (1942).
Deansley, R., and Parkes, A. S., Proc. Roy. Soc., B, 124, 279 (1937).
Folley, S. J., Proc. Roy. Soc., B, 132, 142 (1944).
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BACSICH, P., WYBURN, G. Induction of Heat in Spayed Female Guinea Pigs by Subcutaneous Hormonal Implants. Nature 155, 430 (1945). https://doi.org/10.1038/155430a0
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DOI: https://doi.org/10.1038/155430a0
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