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The INK4a/ARF locus and melanoma

Oncogene volume 22, pages 3092–3098 (2003)Cite this article

Abstract

Inactivation of the INK4a/ARF (or CDKN2a) locus is a common and critical genetic event in the development of human and mouse melanoma. This locus engages the Rb and p53 tumor suppressor pathways through its capacity to encode two distinct gene products, p16INK4a and p14ARF. This review highlights the body of evidence supporting a role for both p16INK4a and p14ARF in the suppression of melanoma, and speculates as to why this locus is preferentially targeted in this tumor type. In addition, the potential importance of these two pathways in mediating UV-induced melanoma genesis will be addressed via genetic and molecular evidence in the mouse.

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Authors and Affiliations

  1. Departments of Medicine and Genetics, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, 27599, NC, USA

    Norman E Sharpless

  2. Department of Medical Oncology, Dana-Farber Cancer Institute, USA

    Lynda Chin

  3. Department of Dermatology, Harvard Medical School, Boston, 02115, MA, USA

    Lynda Chin

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  1. Norman E Sharpless
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Sharpless, N.E., Chin, L. The INK4a/ARF locus and melanoma. Oncogene 22, 3092–3098 (2003). https://doi.org/10.1038/sj.onc.1206461

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