Abstract
Magnetic resonance imaging (MRI) is a technique commonly used to detect neural abnormalities in routine clinical practice. It is perhaps less well known that the technique can be adapted to measure various anatomical and physiological features of small laboratory rodents. This review focuses on the potential of the MRI technique to image the brain of (transgenic) mouse models for neurological diseases, and aims to introduce these exciting new technological developments to the non-specialist reader.
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Financial support for the research performed in Antwerp was obtained through grants from the University of Antwerp, the Belgian National Fund for Scientific Research - Flanders (FWO), the Fragile X research foundation (FRAXA) and from the EC. Research in Vance Lemmon's laboratory is supported by the NEI and NINDS.
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Kooy, R., Verhoye, M., Lemmon, V. et al. Brain studies of mouse models for neurogenetic disorders using in vivo magnetic resonance imaging (MRI). Eur J Hum Genet 9, 153–159 (2001). https://doi.org/10.1038/sj.ejhg.5200606
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DOI: https://doi.org/10.1038/sj.ejhg.5200606