Two forms of a transcription factor, similar in sequence to an rRNA modifying enzyme, have been identified as the missing components of the transcription initiation machinery for human mitochondrial DNA (mtDNA). Transcription from mtDNA promoters can now be reconstituted in vitro with three recombinant proteins: mitochondrial transcription factors A and B and the core mitochondrial RNA polymerase.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Cold-inducible RNA-binding protein through TLR4 signaling induces mitochondrial DNA fragmentation and regulates macrophage cell death after trauma
Cell Death & Disease Open Access 11 May 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Clayton, D.A. Annu. Rev. Cell Biol. 7, 453–478 (1991).
Shadel, G.S. & Clayton, D.A. Annu. Rev. Biochem. 66, 409–435 (1997).
Falkenberg, M. et al. Nature Genet. 31, 289–294 (2002).
Jang, S.H. & Jaehning, J.A. J. Biol. Chem. 266, 22671–22677 (1991).
Masters, B.S., Stohl, L.L. & Clayton, D.A. Cell. 51, 89–99 (1987).
Shadel, G.S. & Clayton, D.A. Mol. Cell. Biol. 15, 2101–2108 (1995).
Larsson, N.G. et al. Nature Genet. 18, 231–236 (1998).
Diffley, J.F. & Stillman, B. Proc. Natl Acad. Sci. USA 88, 7864–7868 (2001).
Dairaghi, D.J., Shadel, G.S. & Clayton, D.A. J. Mol. Biol. 249, 11–28 (1995).
Antoshechkin, I. & Bogenhagen, D.F. Mol. Cell. Biol. 15, 7032–7042 (1995).
McCulloch, V., Seidel-Rogol, B.L. & Shadel, G.S. Mol. Cell. Biol. 22, 1116–1125 (2002).
Schubot, F.D. et al. Protein Sci. 10, 1980–1988 (2001).
Fan, L., Sanschagrin, P.C., Kaguni, L.S. & Kuhn, L.A. Proc. Natl Acad. Sci. USA 96, 9527–9532 (1999).
Carrodeguas, J.A., Kobayashi, R., Lim, S.E., Copeland, W.C. & Bogenhagen, D.F. Mol. Cell. Biol. 19, 4039–4046 (1999).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shoubridge, E. The ABcs of mitochondrial transcription. Nat Genet 31, 227–228 (2002). https://doi.org/10.1038/ng0702-227
Issue Date:
DOI: https://doi.org/10.1038/ng0702-227