Elsevier

Kidney International

Volume 76, Issue 11, 1 December 2009, Pages 1125-1127
Kidney International

Commentary
Advanced oxidation protein products: a causative link between oxidative stress and podocyte depletion

https://doi.org/10.1038/ki.2009.352Get rights and content
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Advanced oxidation protein products (AOPPs), a protein biomarker of increased oxidative stress, are elevated in uremic patients. Zhou et al. demonstrate that chronic administration of AOPPs induces podocyte apoptosis and proteinuria in normal rats via a cascade of signaling events. This study for the first time establishes a causative link between oxidative stress and podocyte depletion and could have broad implications in our understanding of the pathogenic mechanism of proteinuria.

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The author declared no competing interests.