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Diversity of γδ T-cell antigens

Cellular & Molecular Immunology volume 10, pages 13–20 (2013)Cite this article

Abstract

In the last two decades, it has become clear that γδ T cells recognize a diverse array of antigens including self and foreign, large and small, and peptidic and non-peptidic molecules. In this respect, γδ antigens as a whole resemble more the antigens recognized by antibodies than those recognized by αβ T cells. Because of this antigenic diversity, no single mechanism—such as the major histocompatibility complex (MHC) restriction of αβ T cells—is likely to provide a basis for all observed T-cell antigen receptor (TCR)-dependent γδ T-cell responses. Furthermore, available evidence suggests that many individual γδ T cells are poly-specific, probably using different modes of ligand recognition in their responses to unrelated antigens. While posing a unique challenge in the maintenance of self-tolerance, this broad reactivity pattern might enable multiple overlapping uses of γδ T-cell populations, and thus generate a more efficient immune response.

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Authors and Affiliations

  1. Integrated Department of Immunology, National Jewish Health, Denver, CO, USA

    Willi K Born, M Kemal Aydintug & Rebecca L O'Brien

  2. University of Colorado Denver, Aurora, CO, USA

    Willi K Born & Rebecca L O'Brien

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  1. Willi K Born
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  2. M Kemal Aydintug
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  3. Rebecca L O'Brien
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Correspondence to Willi K Born.

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Born, W., Kemal Aydintug, M. & O'Brien, R. Diversity of γδ T-cell antigens. Cell Mol Immunol 10, 13–20 (2013). https://doi.org/10.1038/cmi.2012.45

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