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Reply to: 'Clearance of amyloid β-peptide from brain: transport or metabolism?'

Nature Medicine volume 6, pages 718–719 (2000)Cite this article

Saido et al. reply

We thank Zlokovic et al. for stimulating this speculation about the functions of transport and catabolism in Aβ clearance from brain. Injection of 125I-labeled Aβ peptides into the lateral ventricle of mouse brain has demonstrated that “60% of 125I-Aβ1–40 cleared from the brain in the first 10 min, while only 20% of 125I-Aβ1–42 was cleared from the brain after 45 min.”10 This is consistent with the selective accumulation of Aβ42, but not Aβ40, in rat brain induced by neutral endopeptidase inhibitor infusion1. An appropriate interpretation for these results would be that Aβ40 and Aβ42 are cleared from brain through distinct mechanisms, and that clearance of Aβ40 may be transport-dependent whereas that of Aβ42 is more catabolism-dependent, as we discussed1.

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  1. Laboratory for Proteolytic Neuroscience RIKEN Brain Science Institute,, Wako-shi, 351-0198, Japan

    Nobuhisa Iwata, Satoshi Tsubuki, Emi Hama, Yoshie Takaki, Keiro Shirotani & Takaomi C. Saido

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Iwata, N., Tsubuki, S., Hama, E. et al. Reply to: 'Clearance of amyloid β-peptide from brain: transport or metabolism?'. Nat Med 6, 718–719 (2000). https://doi.org/10.1038/77399

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