Abstract
A variety of studies have shown that some activated nuclear receptors (NRs), especially the glucorticoid receptor, the estrogen receptor and peroxisome proliferator-activated receptor, can inhibit the activity of the transcription factor nuclear factor κB (NF-κB), which plays a key role in the control of genes involved in inflammation, cell proliferation and apoptosis. This review describes the molecular mechanisms of cross-talk between NRs and NF-κB and the biological relevance of this cross-talk. The importance and mechanistic aspects of selective NR modulation are discussed. Also included are future research prospects, which will lead to a new era in the field of NR research with the aim of specifically inhibiting NF-κB-driven gene expression for anti-inflammatory, anti-tumor and immune-modulatory purposes.
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Abbreviations
- AP-1:
-
activator protein-1
- AR:
-
androgen receptor
- Brg1:
-
brahma-related gene 1
- BTM:
-
basal transcription machinery
- CARM:
-
coactivator-associated arginine methyltransferase
- COX:
-
cyclooxygenase
- DBD:
-
DNA-binding domain
- DRIP:
-
vitamin D receptor-interacting protein
- ER:
-
estrogen receptor
- FRAP:
-
fluorescence recovery after photobleaching
- GILZ:
-
glucocorticoid-induced leucine zipper
- GR:
-
glucocorticoid receptor
- GRIP:
-
glucocorticoid receptor-interacting protein
- (n)GRE:
-
(negative) glucocorticoid response element
- HAT:
-
histone acetyltransferase
- HDAC:
-
histone deacetylase
- Hsp:
-
heat shock protein
- IκB:
-
inhibitor κB
- IKK:
-
IκB kinase
- IL:
-
interleukin
- iNOS:
-
inducible nitric oxide synthase
- LBD:
-
ligand-binding domain
- LSD1:
-
lysine-specific histone demethylase 1
- LXR:
-
liver X receptor
- MAPK:
-
mitogen-actived protein kinase
- MKP-1:
-
mitogen-activated protein kinase phosphatase 1
- MMP:
-
matrix metalloproteinase
- MR:
-
mineralocorticoid receptor
- MTA:
-
metastasis-associated protein
- NcoR:
-
nuclear corepressor
- NF-κB:
-
nuclear factor κB
- NR:
-
nuclear receptor
- PGC-1:
-
PPARγ coactivator-1
- PPAR:
-
peroxisome proliferator-activated receptor
- PK:
-
protein kinase
- PLA:
-
phospholipase A
- PR:
-
progesterone receptor
- PSA:
-
prostate-specific antigen
- p-TEFb:
-
transcription elongation factor
- pol:
-
polymerase
- RAR/RXR:
-
retinoid acid receptor/retinoid X receptor
- SEGRM:
-
selective GR modulators
- SERM:
-
selective ER modulators
- SMRT:
-
silencing mediator of retinoic-acid and thyroid hormone receptors
- SRC-1:
-
steroid receptor coactivator-1
- TBL1:
-
transducin-β-like 1
- TF:
-
transcription factor
- TIF:
-
transcription intermediary factor
- TLR:
-
toll-like receptor
- TNF:
-
tumor necrosis factor
- TR:
-
thyroid hormone receptor
- TRAP:
-
thyroid receptor-activated protein
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Acknowledgements
We thank the University of Gent, the IAP and Marató programs, and the FWO-Vlaanderen for financial support. KDB and WVB are postdoctoral fellows with the FWO-Vlaanderen.
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De Bosscher, K., Vanden Berghe, W. & Haegeman, G. Cross-talk between nuclear receptors and nuclear factor κB. Oncogene 25, 6868–6886 (2006). https://doi.org/10.1038/sj.onc.1209935
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DOI: https://doi.org/10.1038/sj.onc.1209935
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