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Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

Oncogene volume 23, pages 4315–4329 (2004)Cite this article

Abstract

We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.

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References

  • Alvarez M, Long H, Onyia J, Hock J, Xu W and Bidwell J . (1997). Endocrinology, 138, 482–489.

  • Aubin JE and Triffitt JT . (2002). Principles of Bone Biology, Bilezikian JP, Raisz LG, and Rodan GA, (ed). Academic Press: San Diego, pp. 59–82.

    Google Scholar 

  • Bae SC, Yamaguchi-Iwai Y, Ogawa E, Maruyama M, Inuzuka M, Kagoshima H, Shigesada K, Satake M and Ito Y . (1993). Oncogene, 8, 809–814.

  • Balint E, Lapointe D, Drissi H, van der Meijden C, Young DW, van Wijnen AJ, Stein JL, Stein GS and Lian JB . (2003). J. Cell. Biochem., 89 (2), 401–426.

  • Banerjee C, Javed A, Choi JY, Green J, Rosen V, van Wijnen AJ, Stein JL, Lian JB and Stein GS . (2001). Endocrinology, 142, 4026–4039.

  • Banerjee C, McCabe LR, Choi J-Y, Hiebert SW, Stein JL, Stein GS and Lian JB . (1997). J. Cell Biochem., 66, 1–8.

  • Bannister AJ, Oehler T, Wilhelm D, Angel P and Kouzarides T . (1995). Oncogene, 11, 2509–2514.

  • Berezney R, Mortillaro M, Ma H, Meng C, Samarabandu J, Wei X, Somanathan S, Liou WS, Pan SJ and Cheng PC . (1996). J. Cell Biochem., 62, 223–226.

  • Bidwell JP, van Wijnen AJ, Fey EG, Dworetzky S, Penman S, Stein JL, Lian JB and Stein GS . (1993). Proc. Natl. Acad. Sci. USA, 90, 3162–3166.

  • Blanco JCG, Wang I-M, Tsai SY, Tsai M-J, O'Malley BW, Jurutka PW, Haussler MR and Ozato K . (1995). Proc. Natl. Acad. Sci. USA, 92, 1535–1539.

  • Blencowe BJ, Nickerson JA, Issner R, Penman S and Sharp PA . (1994). J. Cell Biol., 127, 593–607.

  • Bortell R, Owen TA, Bidwell JP, Gavazzo P, Breen E, van Wijnen AJ, DeLuca HF, Stein JL, Lian JB and Stein GS . (1992). Proc. Natl. Acad. Sci. USA, 89, 6119–6123.

  • Breen EC, van Wijnen AJ, Lian JB, Stein GS and Stein JL . (1994). Proc. Natl. Acad. Sci. USA, 91, 12902–12906.

  • Cameron ER, Blyth K, Hanlon L, Kilbey A, Mackay N, Stewart M, Terry A, Vaillant F, Wotton S and Neil JC . (2003). Blood Cells Mol. Dis., 30, 194–200.

  • Chakravarti D, LaMorte VJ, Nelson MC, Nakajima T, Schulman IG, Juguilon H, Montminy M and Evans RM . (1996). Nature, 383, 99–103.

  • Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y and Evans RM . (1997). Cell, 90, 569–580.

  • Chen HY, Sun JM, Hendzel MJ, Rattner JB and Davie JR . (1996). Biochem. J., 320, 257–265.

  • Chen S, Gu TT, Sreenath T, Kulkarni AB, Karsenty G and MacDougall M . (2002). Connect Tissue Res., 43, 338–344.

  • Choi J-Y, Javed A, Zaidi SK, Lee T, Guo B, Tang L, Zhou GW, van Wijnen AJ, Stein JL and Lian JB . (1999). J. Bone Miner. Res., 14, S469 (Abstract).

  • Choi J-Y, Pratap J, Javed A, Zaidi SK, Xing L, Balint E, Dalamangas S, Boyce B, van Wijnen AJ, Lian JB, Stein JL, Jones SN and Stein GS . (2001). Proc. Natl. Acad. Sci, USA, 98, 8650–8655.

  • Cohen Jr MM . (2001). Am. J. Med. Genet., 104, 185–188.

  • D’Alonzo RC, Selvamurugan N, Karsenty G and Partridge NC . (2002). J. Biol. Chem., 277, 816–822.

  • Davie JR . (1997). Mol. Biol. Rep., 24, 197–207.

  • de Crombrugghe B, Lefebvre V, Behringer RR, Bi W, Murakami S and Huang W . (2000). Matrix Biol., 19, 389–394.

  • DeFranco DB . (2002). Mol. Endocrinol., 16, 1449–1455.

  • Demay MB, Gerardi JM, DeLuca HF and Kronenberg HM . (1990). Proc. Natl. Acad. Sci. USA, 87, 369–373.

  • Drissi H, Luc Q, Shakoori R, Chuva de Sousa Lopes S, Choi J-Y, Terry A, Hu M, Jones S, Neil JC, Lian JB, Stein JL, van Wijnen AJ and Stein GS . (2000). J. Cell Physiol., 184, 341–350.

  • Ducy P and Karsenty G . (1995). Mol. Cell Biol., 15, 1858–1869.

  • Ducy P, Zhang R, Geoffroy V, Ridall AL and Karsenty G . (1997). Cell, 89, 747–754.

  • Dworetzky SI, Wright KL, Fey EG, Penman S, Lian JB, Stein JL and Stein GS . (1992). Proc. Natl. Acad. Sci. USA, 89, 4178–4182.

  • Enomoto H, Enomoto-Iwamoto M, Iwamoto M, Nomura S, Himeno M, Kitamura Y, Kishimoto T and Komori T . (2000). J. Biol. Chem., 275, 8695–8702.

  • Fang MA, Glackin CA, Sadhu A and McDougall S . (2001). J. Cell Biochem., 80, 550–559.

  • Franceschi RT and Xiao G . (2003). J. Cell Biochem., 88, 446–454.

  • Frank R, Zhang J, Uchida H, Meyers S, Hiebert SW and Nimer SD . (1995). Oncogene, 11, 2667–2674.

  • Gasser SM . (2002). Science, 296, 1412–1416.

  • Giese K, Kingsley C, Kirshner JR and Grosschedl R . (1995). Genes Dev., 9, 995–1008.

  • Goodman RH and Smolik S . (2000). Genes Dev., 14, 1553–1577.

  • Gori F, Thomas T, Hicok KC, Spelsberg TC and Riggs BL . (1999). J. Bone Miner Res., 14, 1522–1535.

  • Grande MA, van der Kraan I, de Jong L and van Driel R . (1997). J. Cell Sci., 110, 1781–1791.

  • Guo B, Aslam F, van Wijnen AJ, Roberts SGE, Frenkel B, Green M, DeLuca H, Lian JB, Stein GS and Stein JL . (1997). Proc. Natl. Acad. Sci. USA, 94, 121–126.

  • Guo B, Odgren PR, van Wijnen AJ, Last TJ, Nickerson J, Penman S, Lian JB, Stein JL and Stein GS . (1995). Proc. Natl. Acad. Sci. USA, 92, 10526–10530.

  • Guo WH, Weng LQ, Ito K, Chen LF, Nakanishi H, Tatematsu M and Ito Y . (2002). Oncogene, 21, 8351–8355.

  • Gutierrez S, Javed A, Tennant D, van Rees M, Montecino M, Stein GS, Stein JL and Lian JB . (2002). J. Biol. Chem., 277, 1316–1323.

  • Gutierrez J, Sierra J, Medina R, Puchi M, Imschenetzky M, Hiebert S, van Wijnen A, Lian JB, Stein G, Stein J and Montecino M . (2000). Biochemistry, 39, 13565–13574.

  • Hanai J, Chen LF, Kanno T, Ohtani-Fujita N, Kim WY, Guo WH, Imamura T, Ishidou Y, Fukuchi M, Shi MJ, Stavnezer J, Kawabata M, Miyazono K and Ito Y . (1999). J. Biol. Chem., 274, 31577–31582.

  • Harada H, Tagashira S, Fujiwara M, Ogawa S, Katsumata T, Yamaguchi A, Komori T and Nakatsuka M . (1999). J. Biol. Chem., 274, 6972–6978.

  • Harrington KS, Javed A, Drissi H, McNeil S, Lian JB, Stein JL, van Wijnen AJ, Wang Y-L and Stein GS . (2002). J. Cell Sci., 115, 4167–4176.

  • Hoffmann HM, Catron KM, van Wijnen AJ, McCabe LR, Lian JB, Stein GS and Stein JL . (1994). Proc. Natl. Acad. Sci. USA, 91, 12887–12891.

  • Jackson DA . (1997). Mol. Biol. Rep., 24, 209–220.

  • Javed A, Barnes GL, Jassanya BO, Stein JL, Gerstenfeld L, Lian JB and Stein GS . (2001). Mol. Cell Biol., 21, 2891–2905.

  • Javed A, Guo B, Hiebert S, Choi J-Y, Green J, Zhao S-C, Osborne MA, Stifani S, Stein JL, Lian JB, van Wijnen AJ and Stein GS . (2000). J. Cell Sci., 113, 2221–2231.

  • Javed A, Gutierrez S, Montecino M, van Wijnen AJ, Stein JL, Stein GS and Lian JB . (1999). Mol. Cell Biol., 19, 7491–7500.

  • Ji C, Casinghino S, Chang DJ, Chen Y, Javed A, Ito Y, Hiebert SW, Lian JB, Stein GS, McCarthy TL and Centrella M . (1998). J. Cell Biochem., 69, 353–363.

  • Karsenty G . (2003). Nature, 423, 316–318.

  • Kitabayashi I, Yokoyama A, Shimizu K and Ohki M . (1998). EMBO J., 17, 2994–3004.

  • Komori T . (2002). J. Cell Biochem., 87, 1–8.

  • Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao Y-H, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S and Kishimoto T . (1997). Cell, 89, 755–764.

  • Kowenz-Leutz E and Leutz A . (1999). Mol. Cell, 4, 735–743.

  • Kundu M, Javed A, Jeon JP, Horner A, Shum L, Eckhaus M, Muenke M, Lian JB, Yang Y, Nuckolls GH, Stein GS and Liu PP . (2002). Nat. Genet., 32, 639–644.

  • Lamond AI and Earnshaw WC . (1998). Science, 280, 547–553.

  • Lee KS, Kim HJ, Li QL, Chi XZ, Ueta C, Komori T, Wozney JM, Kim EG, Choi JY, Ryoo HM and Bae SC . (2000). Mol. Cell Biol., 20, 8783–8792.

  • Lee MH, Javed A, Kim HJ, Shin HI, Gutierrez S, Choi JY, Rosen V, Stein JL, van Wijnen AJ, Stein GS, Lian JB and Ryoo HM . (1999). J. Cell Biochem., 73, 114–125.

  • Lengner C, Drissi H, Choi J, van Wijnen AJ, Stein JL, Stein GS and Lian JB . (2001). J. Bone Miner. Res., 16, S366 (Abstract)..

  • Levanon D, Bettoun D, Harris-Cerruti C, Woolf E, Negreanu V, Eilam R, Bernstein Y, Goldenberg D, Xiao C, Fliegauf M, Kremer E, Otto F, Brenner O, Lev-Tov A and Groner Y . (2002). EMBO J., 21, 3454–3463.

  • Levanon D, Brenner O, Negreanu V, Bettoun D, Woolf E, Eilam R, Lotem J, Gat U, Otto F, Speck N and Groner Y . (2001). Mech. Dev., 109, 413–417.

  • Levanon D, Brenner O, Otto F and Groner Y . (2003). EMBO Rep., 4, 560–564.

  • Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifani S, Paroush Z and Groner Y . (1998). Proc. Natl. Acad. Sci. USA, 95, 11590–11595.

  • Li QL, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, Kim HM, Kim WJ, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae SC and Ito Y . (2002). Cell, 109, 113–124.

  • Lian JB, Balint E, Javed A, Drissi H, Vitti R, Quinlan EJ, Zhang L, van Wijnen AJ, Stein JL, Speck N and Stein GS . (2003). J. Cell Physiol., 196, 301–311.

  • Lian JB and Stein GS . (2003). Curr. Pharmaceutical Des., 9 (32), 2677–2685.

  • Lindenmuth DM, van Wijnen AJ, Hiebert S, Stein JL, Lian JB and Stein GS . (1997). J. Cell Biochem., 66, 123–132.

  • Liu F, Aubin JE and Malaval L . (2002). Bone, 31, 212–219.

  • Liu W, Toyosawa S, Furuichi T, Kanatani N, Yoshida C, Liu Y, Himeno M, Narai S, Yamaguchi A and Komori T . (2001). J. Cell Biol., 155, 157–166.

  • Ma H, Samarabandu J, Devdhar RS, Acharya R, Cheng PC, Meng C and Berezney R . (1998). J. Cell Biol., 143, 1415–1425.

  • Ma H, Siegel AJ and Berezney R . (1999). J. Cell Biol., 146, 531–542.

  • MacDonald PN, Sherman DR, Dowd DR, Jefcoat Jr SC and DeLisle RK . (1995). J. Biol. Chem., 270, 4748–4752.

  • Mancini MA, Shan B, Nickerson JA, Penman S and Lee WH . (1994). Proc. Natl. Acad. Sci. USA, 91, 418–422.

  • Mao S, Frank RC, Zhang J, Miyazaki Y and Nimer SD . (1999). Mol. Cell Biol., 19, 3635–3644.

  • Markose ER, Stein JL, Stein GS and Lian JB . (1990). Proc. Natl. Acad. Sci. USA, 87, 1701–1705.

  • McNeil S, Guo B, Stein JL, Lian JB, Bushmeyer S, Seto E, Atchison ML, Penman S, van Wijnen AJ and Stein GS . (1998). J. Cell Biochem., 68, 500–510.

  • McNeil S, Zeng C, Harrington KS, Hiebert S, Lian JB, Stein JL, van Wijnen AJ and Stein GS . (1999). Proc. Natl. Acad. Sci. USA, 96, 14882–14887.

  • Merriman HL, van Wijnen AJ, Hiebert S, Bidwell JP, Fey E, Lian J, Stein J and Stein GS . (1995). Biochemistry, 34, 13125–13132.

  • Meyers S, Downing JR and Hiebert SW . (1993). Mol. Cell Biol., 13, 6336–6345.

  • Meyers S, Lenny N and Hiebert SW . (1995). Mol. Cell Biol., 15, 1974–1982.

  • Meyers S, Lenny N, Sun W-H and Hiebert SW . (1996). Oncogene, 13, 303–312.

  • Miller J, Horner A, Stacy T, Lowrey C, Lian JB, Stein G, Nuckolls GH and Speck NA . (2002). Nat. Genet., 32, 645–649.

  • Mink S, Haenig B and Klempnauer KH . (1997). Mol. Cell Biol., 17, 6609–6617.

  • Mody N, Tintut Y, Radcliff K and Demer LL . (2003). J. Nucl. Cardiol., 10, 177–183.

  • Montecino M, Frenkel B, van Wijnen AJ, Lian JB, Stein GS and Stein JL . (1999). Biochemistry, 38, 1338–1345.

  • Montecino M, Lian J, Stein G and Stein J . (1994). J. Bone Miner Res., 9, S352 (abstract)..

  • Montecino M, Lian J, Stein G and Stein J . (1996). Biochemistry, 35, 5093–5102.

  • Mueller E, Drori S, Aiyer A, Yie J, Sarraf P, Chen H, Hauser S, Rosen ED, Ge K, Roeder RG and Spiegelman BM . (2002). J. Biol. Chem., 277, 41925–41930.

  • Mundlos S, Otto F, Mundlos C, Mulliken JB, Aylsworth AS, Albright S, Lindhout D, Cole WG, Henn W, Knoll JHM, Owen MJ, Mertelsmann R, Zabel BU and Olsen BR . (1997). Cell, 89, 773–779.

  • Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR and de Crombrugghe B . (2002). Cell, 108, 17–29.

  • Nardozza TA, Quigley MM and Getzenberg RH . (1996). J. Cell Biochem., 61, 467–477.

  • Nickerson JA, Blencowe BJ and Penman S . (1995). Structural and Functional Organization of the Nuclear Matrix, Berezney R and Jeon KW, (eds). Academic Press: New York, pp. 67–123.

    Google Scholar 

  • North T, Gu TL, Stacy T, Wang Q, Howard L, Binder M, Marin-Padilla M and Speck NA . (1999). Development, 126 (11), 2563–2575.

  • Nuchprayoon I, Meyers S, Scott LM, Suzow J, Hiebert SW and Friedman AD . (1994). Mol. Cell Biol., 14, 5558–5568.

  • Oelgeschlager M, Janknecht R, Krieg J, Schreek S and Luscher B . (1996). EMBO J., 15, 2771–2780.

  • Ogawa E, Inuzuka M, Maruyama M, Satake M, Naito-Fujimoto M, Ito Y and Shigesada K . (1993a). Virology, 194, 314–331.

  • Ogawa E, Maruyama M, Kagoshima H, Inuzuka M, Lu J, Satake M, Shigesada K and Ito Y . (1993b). Proc. Natl. Acad. Sci. USA, 90, 6859–6863.

  • Ogryzko VV, Schiltz RL, Russanova V, Howard BH and Nakatani Y . (1996). Cell, 87, 953–959.

  • Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GWH, Beddington RSP, Mundlos S, Olsen BR, Selby PB and Owen MJ . (1997). Cell, 89, 765–771.

  • Pardali E, Xie XQ, Tsapogas P, Itoh S, Arvanitidis K, Heldin CH, ten Dijke P, Grundstrom T and Sideras P . (2000). J. Biol. Chem., 275, 3552–3560.

  • Paredes R, Gutierrez J, Gutierrez S, Allison L, Puchi M, Imschenetzky M, van Wijnen A, Lian J, Stein G, Stein J and Montecino M . (2002). Biochem. J., 363, 667–676.

  • Pratap J, Galindo M, Zaidi SK, Vradii D, Bhat BM, Robinson JA, Choi J-Y, Komori T, Stein JL, Lian JB, Stein GS and van Wijnen AJ . (2003). Cancer Res., 63 (17), 5357–5362.

  • Puig-Kroger A, Sanchez-Elsner T, Ruiz N, Andreu EJ, Prosper F, Jensen UB, Gil J, Erickson P, Drabkin H, Groner Y and Corbi AL . (2003). Blood, 102 (9), 3252–3261.

  • Ryoo H-M, Hoffmann HM, Beumer TL, Frenkel B, Towler DA, Stein GS, Stein JL, van Wijnen AJ and Lian JB . (1997). Mol. Endocrinol., 11, 1681–1694.

  • Satake M, Nomura S, Yamaguchi-Iwai Y, Takahama Y, Hashimoto Y, Niki M, Kitamura Y and Ito Y . (1995). Mol. Cell Biol., 15, 1662–1670.

  • Selvamurugan N, Chou WY, Pearman AT, Pulumati MR and Partridge NC . (1998). J. Biol. Chem., 273, 10647–10657.

  • Selvamurugan N, Pulumati MR, Tyson DR and Partridge NC . (2000). J. Biol. Chem., 275, 5037–5042.

  • Shen J, Hovhannisyan H, Lian JB, Montecino MA, Stein GS, Stein JL and van Wijnen AJ . (2003). Mol. Endocrinol., 17, 743–756.

  • Shen J, Montecino MA, Lian JB, Stein GS, van Wijnen AJ and Stein JL . (2002). J. Biol. Chem., 277, 20284–20292.

  • Sierra J, Villagra A, Paredes R, Cruzat F, Gutierrez S, Arriagada G, Olate J, Imschenetzky M, van Wijnen AJ, Lian JB, Stein GS, Stein JL and Montecino M . (2003). Mol. Cell Biol., 23, 3339–3351.

  • Speck NA and Stacy T . (1995). Crit. Rev. Eukary Gene Expr., 5, 337–364.

  • Speck NA, Stacy T, Wang Q, North T, Gu TL, Miller J, Binder M and Marin-Padilla M . (1999). Cancer Res., 59, 1789s–1793s.

  • Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou J, Mizzen CA, McKenna NJ, Onate SA, Tsai SY, Tsai MJ and O'Malley BW . (1997). Nature, 389, 194–198.

  • Spencer VA and Davie JR . (1999). Gene, 240, 1–12.

  • Stein GS, Montecino M, van Wijnen AJ, Stein JL and Lian JB . (2000a). Cancer Res., 60, 2067–2076.

  • Stein GS, Stein JL, Lian JB, van Wijnen AJ and Montecino M . (1996). J. Cell Biochem., 62, 198–209.

  • Stein GS, van Wijnen AJ, Stein JL, Lian JB, Montecino M, Choi J-Y, Zaidi K and Javed A . (2000b). J. Cell Sci., 113, 2527–2533.

  • Stewart M, Terry A, Hu M, O'Hara M, Blyth K, Baxter E, Cameron E, Onions DE and Neil JC . (1997). Proc. Natl. Acad. Sci. USA, 94, 8646–8651.

  • Stricker S, Fundele R, Vortkamp A and Mundlos S . (2002). Dev. Biol., 245, 95–108.

  • Sun L, Vitolo M and Passaniti A . (2001). Cancer Res., 61, 4994–5001.

  • Takeda S, Bonnamy JP, Owen MJ, Ducy P and Karsenty G . (2001). Genes. Dev., 15, 467–481.

  • Tamura M and Noda M . (1994). J. Cell Biol., 126, 773–782.

  • Tang L, Guo B, Javed A, Choi JY, Hicbert S, Lian JB, van Wijnen AJ, Stein JL, Stein GS and Zhou GW . (1999). J. Biol. Chem., 274 (47), 33580–33586.

  • Tang QQ, Otto TC and Lane MD . (2003). Proc. Natl. Acad. Sci. USA, 100, 850–855.

  • Thirunavukkarasu K, Halladay DL, Miles RR, Yang X, Galvin RJ, Chandrasekhar S, Martin TJ and Onyia JE . (2000). J. Biol. Chem., 275, 25163–25172.

  • Thomas DM, Carty SA, Piscopo DM, Lee JS, Wang WF, Forrester WC and Hinds PW . (2001). Molec. Cell, 8, 303–316.

  • Torchia J, Rose DW, Inostroza J, Kamei Y, Westin S, Glass CK and Rosenfeld MG . (1997). Nature, 387, 677–684.

  • Ueta C, Iwamoto M, Kanatani N, Yoshida C, Liu Y, Enomoto-Iwamoto M, Ohmori T, Enomoto H, Nakata K, Takada K, Kurisu K and Komori T . (2001). J. Cell Biol., 153, 87–100.

  • Vaes BLT, Dechering KJ, Feijen A, Hendriks JMA, Lefevre C, Mummery C, Olijve W, Van zoelen EJ and Steegenga WT . (2002). J. Bone Miner Res., 17, 2106–2118.

  • Vaillant F, Blyth K, Andrew L, Neil JC and Cameron ER . (2002). J. Immunol., 169, 2866–2874.

  • van Wijnen AJ, Bidwell JP, Fey EG, Penman S, Lian JB, Stein JL and Stein GS . (1993). Biochemistry, 32, 8397–8402.

  • van Wijnen AJ, Stein GS, Stein JL and Lian JB . (2003). Cell Cycle Inhibitors in Cancer Therapy: Current Strategies, Giordano A and Soprano KJ, (eds). Humana Press, Inc.: Totowa, NJ, pp 31–48.

    Google Scholar 

  • Villagra A, Gutierrez J, Paredes R, Sierra J, Puchi M, Imschenetzky M, Wijnen AA, Lian J, Stein G, Stein J and Montecino M . (2002). J. Cell Biochem., 85, 112–122.

  • Wang S, Wang Q, Crute BE, Melnikova IN, Keller SR and Speck NA . (1993). Mol. Cell Biol., 13, 3324–3339.

  • Wei X, Samarabandu J, Devdhar RS, Siegel AJ, Acharya R and Berezney R . (1998). Science, 281, 1502–1505.

  • Wei X, Somanathan S, Samarabandu J and Berezney R . (1999). J. Cell Biol., 146, 543–558.

  • Westendorf JJ, Yamamoto CM, Lenny N, Downing JR, Selsted ME and Hiebert SW . (1998). Mol. Cell Biol., 18, 322–333.

  • Westendorf JJ, Zaidi SK, Cascino JE, Kahler R, van Wijnen AJ, Lian JB, Yoshida M, Stein GS and Li X . (2002). Mol. Cell Biol., 22, 7982–7992.

  • Xie XQ, Pardali E, Holm M, Sideras P and Grundstrom T . (1999). Eur. J. Immunol., 29, 488–498.

  • Yang XJ, Ogryzko VV, Nishikawa J, Howard BH and Nakatani Y . (1996). Nature, 382, 319–324.

  • Zaidi SK, Sullivan AJ, Medina R, Ito Y, van Wijnen AJ, Stein JL, Stein GS and Lian JB . (2004). EMBOJ., 23 (4), 790–799.

  • Zaidi SK, Sullivan AJ, van Wijnen AJ, Stein JL, Stein GS and Lian JB . (2002). Proc Natl Acad Sci, USA, 99, 8048–8053.

  • Zaidi SK, Young DW, Pockwinse SH, Javed A, Lian JB, Stein JL, van Wijnen AJ and Stein GS . (2003). Proc. Natl. Acad. Sci. USA, 100 (25), 14852–14857.

  • Zelzer E, Glotzer DJ, Hartmann C, Thomas D, Fukai N, Soker S and Olsen BR . (2001). Mech. Dev., 106, 97–106.

  • Zeng C, McNeil S, Pockwinse S, Nickerson JA, Shopland L, Lawrence JB, Penman S, Hiebert SW, Lian JB, van Wijnen AJ, Stein JL and Stein GS . (1998). Proc. Natl. Acad. Sci. USA, 95, 1585–1589.

  • Zeng C, van Wijnen AJ, Stein JL, Meyers S, Sun W, Shopland L, Lawrence JB, Penman S, Lian JB, Stein GS and Hiebert SW . (1997). Proc. Natl. Acad. Sci. USA, 94, 6746–6751.

  • Zhang DE, Hetherington CJ, Meyers S, Rhoades KL, Larson CJ, Chen HM, Hiebert SW and Tenen DG . (1996). Mol. Cell. Biol., 16, 1231–1240.

  • Zhang X, Aubin JE and Inman RD . (2003). Curr. Opin. Rheumatol., 15, 387–393.

  • Zhang YW, Yasui N, Ito K, Huang G, Fujii M, Hanai J, Nogami H, Ochi T, Miyazono K and Ito Y . (2000a). Proc. Natl. Acad.Sci. USA, 97, 10549–10554.

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Acknowledgements

Results presented in this paper were in part supported by grants for the National Institutes of Health (AR45688, PO1CA82834, DE12528, AR39588, AR45689, PO1AR48818, FIRCA R03 TW00990, FONDECYT 1030479). We appreciate the editorial assistance of Elizabeth Bronstein with the preparation of this paper.

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Authors and Affiliations

  1. Department of Cell Biology and Cancer Center University of Massachusetts Medical School, Worcester, MA, USA

    Gary S Stein, Jane B Lian, Andre J van Wijnen, Janet L Stein, Amjad Javed, Sayyed K Zaidi, Daniel W Young & Shirwin M Pockwinse

  2. Departamento de Biologia Molecular, Universidad de Concepcion, Chile

    Martin Montecino

  3. Department of Biochemisty, School of Medicine, Skeletal Diseases Genome Research Center, Kyungpook National University, Daegu, Korea

    Je-Yong Choi

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  1. Gary S Stein
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  2. Jane B Lian
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  3. Andre J van Wijnen
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  4. Janet L Stein
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  5. Martin Montecino
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  10. Shirwin M Pockwinse
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Correspondence to Gary S Stein.

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Stein, G., Lian, J., Wijnen, A. et al. Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene 23, 4315–4329 (2004). https://doi.org/10.1038/sj.onc.1207676

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