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Atypical fluorescence in situ hybridisation pattern in chronic myeloid leukaemia due to cryptic insertion of BCR at 9q34

Leukemia volume 18, pages 161–162 (2004)Cite this article

TO THE EDITOR

We read with interest the recent paper by Primo et al1 that describes atypical interphase fluorescence in situ hybridisation (FISH) patterns of BCR/ABL gene rearrangement in chronic myeloid leukaemia (CML) and Ph-positive acute leukaemia. In particular, the loss of one red signal in BCR/ABL dual colour extra signal (ES) probe system is found to be genetically heterogeneous, and may represent either derivative chromosome 9q deletions or cryptic insertion of BCR at 9q34. While the former aberration is well described,2 the latter event is unusual3 and has hitherto not been thoroughly evaluated using different readily available FISH probe systems. We present the atypical FISH patterns in a case of CML with BCR/ABL fusion on 9q as a result of cryptic insertion of BCR at 9q34, and discuss their interpretation.

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References

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Authors and Affiliations

  1. Department of Pathology, Division of Haematology, The University of Hong Kong, Queen Mary Hospital, Hong Kong

    T S K Wan, S K Ma & L C Chan

  2. Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Kowloon, Hong Kong

    C K Li

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  1. T S K Wan
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  2. S K Ma
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Correspondence to S K Ma.

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Wan, T., Ma, S., Li, C. et al. Atypical fluorescence in situ hybridisation pattern in chronic myeloid leukaemia due to cryptic insertion of BCR at 9q34. Leukemia 18, 161–162 (2004). https://doi.org/10.1038/sj.leu.2403197

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