Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Perinatal/Neonatal Case Presentation: Neonatal Acute Renal Failure Secondary to Maternal Exposure to Telmisartan, Angiotensin II Receptor Antagonist

Journal of Perinatology volume 23, pages 254–255 (2003)Cite this article

Abstract

Fetal and neonatal toxic effects of angiotensin II receptor antagonists have been described in animals and humans. Five cases of fetal or neonatal deaths have been reported following maternal use of sartans for hypertension. We report a case of neonatal transient renal failure following telmisartan therapy during pregnancy. This class of antihypertensive drugs should be avoided during pregnancy and breastfeeding.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Pryde PG, Sedman AB, Nugent CE . Angiotensin-converting enzyme inhibitor fetopathy. J Am Soc Nephrol 1993;3:1575–1582.

    CAS  PubMed  Google Scholar 

  2. Barr M . Teratogen update: Angiotensin-converting enzyme inhibitors. Teratology 1995;50:399–409.

    Article  Google Scholar 

  3. Spence SG, Allen HL, Cukierski MA et al. Defining the susceptible period of developmental toxicity for the AT1-selective angiotensin II receptor antagonist losartan in rats. Teratology 1995;51:367–382.

    Article  CAS  Google Scholar 

  4. Spence SG, Zacchei AG, Lee LL et al. Teratology 1996;53:245–252.

    Article  CAS  Google Scholar 

  5. Saji H, Yamanaka M, Hagiwara A, Ijiri R . Losartan and fetal toxic effects. Lancet 2001;357:363.

    Article  CAS  Google Scholar 

  6. Martinovic J, Benachi A, Laurent N, Daïka-Dahmane F, Gubler MC . Fetal toxic effects and angiotensin-II receptor antagonists. Lancet 2001;358:241–242.

    Article  CAS  Google Scholar 

  7. Briggs GG, Nageotte MP . Fatal fetal outcome with the combined use of valsartan and atenolol. Ann Pharmacoth 2001;35:859–861.

    Article  CAS  Google Scholar 

  8. Sorensen AM, Christensen S, Jonassen TE, Andersen D, Petersen JS . Teratogenic effects of ACE-inhibitors and angiotensin-II receptor antagonists. Ugeskrift for Laeger 1998;160:1460–1464.

    CAS  PubMed  Google Scholar 

  9. Website of the European Agency for the evaluation of medicinal products. http://www.eudra.org/humandocs/human/epar/telmisartan/telmisartan.htm

  10. Vidal, editor. Le Dictionnaire. France: Boehringer Ingelheim; 2002. p. 1125.

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, American Memorial Hospital, Reims, France

    Christine Pietrement MD, Lilia Malot MD, Brigitte Santerne MD, Bernard Roussel MD, Jacques Motte MD & Patrice Morville MD

Authors
  1. Christine Pietrement MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lilia Malot MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Brigitte Santerne MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bernard Roussel MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jacques Motte MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Patrice Morville MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pietrement, C., Malot, L., Santerne, B. et al. Perinatal/Neonatal Case Presentation: Neonatal Acute Renal Failure Secondary to Maternal Exposure to Telmisartan, Angiotensin II Receptor Antagonist. J Perinatol 23, 254–255 (2003). https://doi.org/10.1038/sj.jp.7210871

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.jp.7210871

This article is cited by

Search

Advanced search

Quick links