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Absence of genetic variation in some obesity candidate genes (GLP1R, ASIP, MC4R, MC5R) among Pima Indians

International Journal of Obesity volume 23, pages 163–165 (1999)Cite this article

Abstract

OBJECTIVE: To examine the obesity candidate genes glucagon-like-peptide receptor (GLP1R), agouti signaling protein (ASIP) and the melanocortin receptors 4 and 5 (MC4R and MC5R) for DNA polymorphisms in their coding regions.

SUBJECTS: Unrelated, non-diabetic Pima Indians (8 to 12 from each extreme of body fat).

MEASUREMENTS: DNA sequencing within the coding regions of each gene.

RESULT: Only one variant was detected, a silent substitution in exon 6 of GLP1R.

CONCLUSION: The exclusion of any common amino-acid polymorphisms (allele frequency ≥0.20). implies that structural variants of these genes do not contribute to variation in the high level of obesity observed among the Pima Indians.

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Authors and Affiliations

  1. Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona

    RA Norman, P Permana & E Ravussin

  2. Third Department of Internal Medicine, Yamaguchi University, School of Medicine, Yamaguchi, Japan

    Y Tanizawa

Authors
  1. RA Norman
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  2. P Permana
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  3. Y Tanizawa
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  4. E Ravussin
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Correspondence to RA Norman.

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Norman, R., Permana, P., Tanizawa, Y. et al. Absence of genetic variation in some obesity candidate genes (GLP1R, ASIP, MC4R, MC5R) among Pima Indians. Int J Obes 23, 163–165 (1999). https://doi.org/10.1038/sj.ijo.0800786

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  • DOI: https://doi.org/10.1038/sj.ijo.0800786

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