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Concurrent presence of both patient and donor t(14;18) in a follicular lymphoma patient after undergoing allogeneic BMT: implications for minimal residual disease detection post-transplant

Bone Marrow Transplantation volume 31, pages 947–949 (2003)Cite this article

Summary:

We report the case of a t(14:18)+ follicular lymphoma (FL) patient in long-term clinical remission after undergoing an allogeneic bone marrow transplantation (allo-BMT) from a human leukocyte antigen (HLA)-identical sibling donor who was the normal healthy carrier of a t(14:18)+ B cell clone. Using real-time quantitative PCR (RQ-PCR) and gel electrophoresis, we document the temporal disappearance of the patient's t(14:18)+ clone early post-transplant with the concomitant emergence and long-term persistence of the donor's t(14:18)+ clone in the patient's peripheral blood. This report indicates that the use of PCR-based techniques to measure minimal residual disease in FL patients post-alloBMT should incorporate pretransplant screening of the donor for t(14;18). Furthermore, it suggests that healthy individuals with t(14:18) need not be excluded as donors for FL patients treated with allo-BMT.

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Authors and Affiliations

  1. Department of Medical Scientist Training Program (MSTP), Medical College of Wisconsin, Milwaukee, WI, USA

    M D Rosenblum

  2. Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA

    W R Drobyski & C Keever-Taylor

  3. Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA

    C-C Chang

Authors
  1. M D Rosenblum
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  2. W R Drobyski
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  3. C Keever-Taylor
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  4. C-C Chang
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Rosenblum, M., Drobyski, W., Keever-Taylor, C. et al. Concurrent presence of both patient and donor t(14;18) in a follicular lymphoma patient after undergoing allogeneic BMT: implications for minimal residual disease detection post-transplant. Bone Marrow Transplant 31, 947–949 (2003). https://doi.org/10.1038/sj.bmt.1704039

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  • DOI: https://doi.org/10.1038/sj.bmt.1704039

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