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Viral Complications

Inverse relationship between human herpesvirus-6 and -7 detection after allogeneic and autologous stem cell transplantation

Bone Marrow Transplantation volume 27, pages 1065–1070 (2001)Cite this article

Abstract

Human herpesvirus-6 (HHV-6) and -7 were analyzed in 25 and 18 patients with allogeneic (allo) and autologous (auto) stem cell transplantation (SCT), respectively, by weekly examination of viral DNA in peripheral mononuclear cells using semiquantitative PCR and serologic tests up to 12 weeks after SCT. HHV-6 DNA was detected in 29.6% and 27.9% of samples after allo- and auto-SCT, respectively. The proportions of HHV-6-DNA-positive samples increased in week 3 and 4 after allo-SCT, and in week 1 to 3 after auto-SCT. The frequency of HHV-7 DNA detection, however, was higher after auto-SCT (24.7%) than allo-SCT (12.8%) (P < 0.01). antibody titer elevation was accompanied by hhv-6 infection in eight of 10 patients. that for hhv-7 was also frequently observed, but not associated with infection in the majority of patients. five of six patients with >102 copies of HHV-6 DNA (/105 cells) on two consecutive occasions were allo-SCT recipients and three showed clinical episodes. Conversely, three of five patients with continuous reactivation of HHV-7 were auto-SCT recipients. Thus, the frequencies of HHV-6 and -7 DNA detection showed an inverse relationship comparing allo- and auto-SCT, suggesting a different mechanism may regulate HHV-6 and -7 reactivation. Bone Marrow Transplantation (2001) 27, 1065–1070.

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Acknowledgements

This study was supported in part by a Grant-in Aid from the Ministry of Education, Science and Culture of Japan. We thank T Aono of Toyobo Chemical Co. for the synthesis of DNA primers and probes.

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Authors and Affiliations

  1. Department of Developmental Medicine D-5, Osaka University, Graduate School of Medicine, Suita, Japan

    H Miyoshi, K Tanaka-Taya, J Hara, H Fujisaki, Y Matsuda, H Ohta, Y Osugi & S Okada

  2. Department of Microbiology C-1, Osaka University, Graduate School of Medicine, Suita, Japan

    K Yamanishi

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  1. H Miyoshi
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Miyoshi, H., Tanaka-Taya, K., Hara, J. et al. Inverse relationship between human herpesvirus-6 and -7 detection after allogeneic and autologous stem cell transplantation. Bone Marrow Transplant 27, 1065–1070 (2001). https://doi.org/10.1038/sj.bmt.1703033

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