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Autonomous experiments using active learning and AI

Active learning and automation will not easily liberate humans from laboratory workflows. Before they can really impact materials research, artificial intelligence systems will need to be carefully set up to ensure their robust operation and their ability to deal with both epistemic and stochastic errors. As autonomous experiments become more widely available, it is essential to think about how to embed reproducibility, reconfigurability and interoperability in the design of autonomous labs.

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Fig. 1: Future outlook: autonomous labs connected in an AI network.

References

  1. Morgan, D. et al. Machine learning in nuclear materials research. Curr. Opin. Solid State Mater. Sci. 26, 100975 (2022).

    Article  CAS  Google Scholar 

  2. Coley, C. W., Eyke, N. S. & Jensen, K. F. Autonomous discovery in the chemical sciences part II: outlook. Angew. Chem. Int. Ed. 59, 23414–23436 (2020).

    Article  CAS  Google Scholar 

  3. Burger, B. et al. A mobile robotic chemist. Nature 583, 237–241 (2020).

    Article  CAS  Google Scholar 

  4. Chen, J. et al. Navigating phase diagram complexity to guide robotic inorganic materials synthesis. Preprint at https://arxiv.org/abs/2304.00743 (2023).

  5. Stach, E. et al. Autonomous experimentation systems for materials development: a community perspective. Matter 4, 2702–2726 (2021).

    Article  Google Scholar 

  6. Siemenn, A. E., Ren, Z., Li, Q. & Buonassisi, T. Fast Bayesian optimization of needle-in-a-haystack problems using zooming memory-based initialization (ZoMBI). npj Comp. Mater. 9, 79 (2023).

    Article  Google Scholar 

  7. Baker, M. 1,500 scientists lift the lid on reproducibility. Nature 533, 452–454 (2016).

    Article  CAS  Google Scholar 

  8. Park, Y. J. et al. Can ChatGPT be used to generate scientific hypotheses? Preprint at https://arxiv.org/abs/2304.12208 (2023).

  9. Arnold, C. Cloud labs: where robots do the research. Nature 606, 612–613 (2022).

    Article  CAS  Google Scholar 

  10. Ren, Z. C., Zhang, Z., Tian Y. S. & Li, J. CRESt – Copilot for Real-world Experimental Scientist. Preprint at https://doi.org/10.26434/chemrxiv-2023-tnz1x (2023).

Download references

Acknowledgements

The authors thank Y. Tian for insightful discussions and R. S. Indradjaja for giving feedback on the manuscript. They acknowledge support by DTRA (award no. HDTRA1-20-2-0002) Interaction of Ionizing Radiation with Matter (IIRM) University Research Alliance (URA).

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Correspondence to Tonio Buonassisi or Ju Li.

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Competing interests

Zekun Ren and T.B. are co-founders of Xinterra Pte. Ltd, a startup focused on applying active learning to accelerate the development of materials for sustainability. The other authors declare no competing interests.

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Ren, Z., Ren, Z., Zhang, Z. et al. Autonomous experiments using active learning and AI. Nat Rev Mater 8, 563–564 (2023). https://doi.org/10.1038/s41578-023-00588-4

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