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Dynamic responses of the haematopoietic stem cell niche to diverse stresses

Nature Cell Biology volume 22, pages 7–17 (2020)Cite this article

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An Author Correction to this article was published on 22 January 2020

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Abstract

Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal and haematopoietic cells regulate their function. The steady state HSC niche has been extensively studied. In this Review, we focus on how bone marrow microenvironment components respond to different insults including inflammation, malignant haematopoiesis and chemotherapy. We highlight common and unique patterns among multiple cell types and their environment and discuss current limitations in our understanding of this complex and dynamic tissue.

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Fig. 1: In the adult life, haematopoiesis happens in the bone marrow microenvironment, a tightly organized tissue in which cells of different origin and metabolic components act to orchestrate this process during homeostasis.
Fig. 2: HSCs are localised within the bone marrow microenvironment where the various components orchestrate HSC maintenance, quiescence and differentiation.

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Acknowledgements

This Review was supported in parts by the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001045), the UK Medical Research Council (FC001045) and the Wellcome Trust (FC001045) to D.B. and by grants from the European Research Council (ERC STG 337066), the British Biology and Biotechnology Research council (BB/i004033/1) and Bloodwise (15031 and 15040), Cancer Research UK (C36195/A26770) and the Wellcome Trust (212304/Z/18/Z) to C.L.C. A.B. and D.P. are recipients of the Junior EHA fellowship. M.L.R.H. was funded by the Wellcome Trust.

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  1. These authors contributed equally: Antoniana Batsivari, Myriam Luydmila Rachelle Haltalli, Diana Passaro, Constandina Pospori.

Authors and Affiliations

  1. Haematopoietic Stem Cell Laboratory, The Francis Crick Institute , London, UK

    Antoniana Batsivari, Diana Passaro, Constandina Pospori, Cristina Lo Celso & Dominique Bonnet

  2. Department of Life Sciences, Imperial College London, South Kensington campus, London, UK

    Myriam Luydmila Rachelle Haltalli, Constandina Pospori & Cristina Lo Celso

  3. Lo Celso Laboratory, The Francis Crick Institute, London, UK

    Myriam Luydmila Rachelle Haltalli, Constandina Pospori & Cristina Lo Celso

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Batsivari, A., Haltalli, M.L.R., Passaro, D. et al. Dynamic responses of the haematopoietic stem cell niche to diverse stresses. Nat Cell Biol 22, 7–17 (2020). https://doi.org/10.1038/s41556-019-0444-9

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